Six-minute walk test: reference values and prediction equation in healthy boys aged 5 to 12 years.

<h4>Objective</h4>This study aimed to (1) generate normative data in healthy boys aged 5-12 years for the six-minute walk test (6MWT), an outcome measure currently used in clinical trials in Duchenne muscular dystrophy (DMD), (2) to describe the relation with anthropometric variables and...

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Autores principales:	Nathalie Goemans, Katrijn Klingels, Marleen van den Hauwe, Stefanie Boons, Liese Verstraete, Charlotte Peeters, Hilde Feys, Gunnar Buyse
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4e77d09299c4f989a994074876e0f32
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spelling	oai:doaj.org-article:e4e77d09299c4f989a994074876e0f322021-11-18T08:39:24ZSix-minute walk test: reference values and prediction equation in healthy boys aged 5 to 12 years.1932-620310.1371/journal.pone.0084120https://doaj.org/article/e4e77d09299c4f989a994074876e0f322013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24391899/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>This study aimed to (1) generate normative data in healthy boys aged 5-12 years for the six-minute walk test (6MWT), an outcome measure currently used in clinical trials in Duchenne muscular dystrophy (DMD), (2) to describe the relation with anthropometric variables and myometry, and (3) to compare our data with published equations.<h4>Methods</h4>The 6MWT was conducted in 442 boys according to a standardized protocol, as currently used in clinical trials in DMD. Maximal voluntary isometric contractions for knee flexion and extension were recorded with a hand-held myometer.<h4>Results</h4>The 6MWD increased significantly with age, from 478.0 ± 44.1 m at age 5, to 650.0 ± 76.8 m at age 12, with the steepest increase between 5 and 8 years. Age- and height related percentile curves of the 6MWD were developed. Correlations with anthropometric variables were fair to good (age r = 0.60, height r = 0.57, weight r = 0.44). Myometric variables (knee flexors and extensors) showed correlations of 0.46 and 0.50 respectively. When dividing into two age categories (5-8 years, 9-12 years), these magnitudes of correlations only applied to the younger age group. Additionally, predicted values were calculated according to available reference equations (Geiger and Ben Saad), indicating an overestimation by those equations. Finally, the Geiger equation was refitted to our population.<h4>Conclusion</h4>The percentile curves according to age and height provide a useful tool in the assessment of ambulatory capacity in boys aged 5 to 12 years. Significant correlations with anthropometric variables and myometry were only found in the 5-8 years age group. The Geiger prediction equation, currently used to assess ambulatory capacity in DMD was refitted to obtain a more accurate prediction model based on a large sample with a homogenous distribution across the age categories 5 to 12 years and applying the methodology as currently used in clinical trials in DMD.Nathalie GoemansKatrijn KlingelsMarleen van den HauweStefanie BoonsLiese VerstraeteCharlotte PeetersHilde FeysGunnar BuysePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e84120 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nathalie Goemans Katrijn Klingels Marleen van den Hauwe Stefanie Boons Liese Verstraete Charlotte Peeters Hilde Feys Gunnar Buyse Six-minute walk test: reference values and prediction equation in healthy boys aged 5 to 12 years.
description	<h4>Objective</h4>This study aimed to (1) generate normative data in healthy boys aged 5-12 years for the six-minute walk test (6MWT), an outcome measure currently used in clinical trials in Duchenne muscular dystrophy (DMD), (2) to describe the relation with anthropometric variables and myometry, and (3) to compare our data with published equations.<h4>Methods</h4>The 6MWT was conducted in 442 boys according to a standardized protocol, as currently used in clinical trials in DMD. Maximal voluntary isometric contractions for knee flexion and extension were recorded with a hand-held myometer.<h4>Results</h4>The 6MWD increased significantly with age, from 478.0 ± 44.1 m at age 5, to 650.0 ± 76.8 m at age 12, with the steepest increase between 5 and 8 years. Age- and height related percentile curves of the 6MWD were developed. Correlations with anthropometric variables were fair to good (age r = 0.60, height r = 0.57, weight r = 0.44). Myometric variables (knee flexors and extensors) showed correlations of 0.46 and 0.50 respectively. When dividing into two age categories (5-8 years, 9-12 years), these magnitudes of correlations only applied to the younger age group. Additionally, predicted values were calculated according to available reference equations (Geiger and Ben Saad), indicating an overestimation by those equations. Finally, the Geiger equation was refitted to our population.<h4>Conclusion</h4>The percentile curves according to age and height provide a useful tool in the assessment of ambulatory capacity in boys aged 5 to 12 years. Significant correlations with anthropometric variables and myometry were only found in the 5-8 years age group. The Geiger prediction equation, currently used to assess ambulatory capacity in DMD was refitted to obtain a more accurate prediction model based on a large sample with a homogenous distribution across the age categories 5 to 12 years and applying the methodology as currently used in clinical trials in DMD.
format	article
author	Nathalie Goemans Katrijn Klingels Marleen van den Hauwe Stefanie Boons Liese Verstraete Charlotte Peeters Hilde Feys Gunnar Buyse
author_facet	Nathalie Goemans Katrijn Klingels Marleen van den Hauwe Stefanie Boons Liese Verstraete Charlotte Peeters Hilde Feys Gunnar Buyse
author_sort	Nathalie Goemans
title	Six-minute walk test: reference values and prediction equation in healthy boys aged 5 to 12 years.
title_short	Six-minute walk test: reference values and prediction equation in healthy boys aged 5 to 12 years.
title_full	Six-minute walk test: reference values and prediction equation in healthy boys aged 5 to 12 years.
title_fullStr	Six-minute walk test: reference values and prediction equation in healthy boys aged 5 to 12 years.
title_full_unstemmed	Six-minute walk test: reference values and prediction equation in healthy boys aged 5 to 12 years.
title_sort	six-minute walk test: reference values and prediction equation in healthy boys aged 5 to 12 years.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e4e77d09299c4f989a994074876e0f32
work_keys_str_mv	AT nathaliegoemans sixminutewalktestreferencevaluesandpredictionequationinhealthyboysaged5to12years AT katrijnklingels sixminutewalktestreferencevaluesandpredictionequationinhealthyboysaged5to12years AT marleenvandenhauwe sixminutewalktestreferencevaluesandpredictionequationinhealthyboysaged5to12years AT stefanieboons sixminutewalktestreferencevaluesandpredictionequationinhealthyboysaged5to12years AT lieseverstraete sixminutewalktestreferencevaluesandpredictionequationinhealthyboysaged5to12years AT charlottepeeters sixminutewalktestreferencevaluesandpredictionequationinhealthyboysaged5to12years AT hildefeys sixminutewalktestreferencevaluesandpredictionequationinhealthyboysaged5to12years AT gunnarbuyse sixminutewalktestreferencevaluesandpredictionequationinhealthyboysaged5to12years
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Six-minute walk test: reference values and prediction equation in healthy boys aged 5 to 12 years.

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