Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19
Longitudinal analyses are needed to show how the immune response to Sars-Cov-2 infection changes over time. Here, the authors use multiple strategies to profile the change in immune cell responses from patients with convalescent COVID-19 over the course of ~5 months, showing that although neutralizi...
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Nature Portfolio
2021
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oai:doaj.org-article:e4e8f1c116754d5288a334fd4274b5ac2021-12-02T14:21:24ZEvolution of immune responses to SARS-CoV-2 in mild-moderate COVID-1910.1038/s41467-021-21444-52041-1723https://doaj.org/article/e4e8f1c116754d5288a334fd4274b5ac2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21444-5https://doaj.org/toc/2041-1723Longitudinal analyses are needed to show how the immune response to Sars-Cov-2 infection changes over time. Here, the authors use multiple strategies to profile the change in immune cell responses from patients with convalescent COVID-19 over the course of ~5 months, showing that although neutralizing antibody responses drop off after ~4 months, B cell immune responses strengthen.Adam K. WheatleyJennifer A. JunoJing J. WangKevin J. SelvaArnold ReynaldiHyon-Xhi TanWen Shi LeeKathleen M. WraggHannah G. KellyRobyn EsterbauerSamantha K. DavisHelen E. KentFrancesca L. MordantTimothy E. SchlubDavid L. GordonDavid S. KhouryKanta SubbaraoDeborah CromerTom P. GordonAmy W. ChungMiles P. DavenportStephen J. KentNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Adam K. Wheatley Jennifer A. Juno Jing J. Wang Kevin J. Selva Arnold Reynaldi Hyon-Xhi Tan Wen Shi Lee Kathleen M. Wragg Hannah G. Kelly Robyn Esterbauer Samantha K. Davis Helen E. Kent Francesca L. Mordant Timothy E. Schlub David L. Gordon David S. Khoury Kanta Subbarao Deborah Cromer Tom P. Gordon Amy W. Chung Miles P. Davenport Stephen J. Kent Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19 |
| description |
Longitudinal analyses are needed to show how the immune response to Sars-Cov-2 infection changes over time. Here, the authors use multiple strategies to profile the change in immune cell responses from patients with convalescent COVID-19 over the course of ~5 months, showing that although neutralizing antibody responses drop off after ~4 months, B cell immune responses strengthen. |
| format |
article |
| author |
Adam K. Wheatley Jennifer A. Juno Jing J. Wang Kevin J. Selva Arnold Reynaldi Hyon-Xhi Tan Wen Shi Lee Kathleen M. Wragg Hannah G. Kelly Robyn Esterbauer Samantha K. Davis Helen E. Kent Francesca L. Mordant Timothy E. Schlub David L. Gordon David S. Khoury Kanta Subbarao Deborah Cromer Tom P. Gordon Amy W. Chung Miles P. Davenport Stephen J. Kent |
| author_facet |
Adam K. Wheatley Jennifer A. Juno Jing J. Wang Kevin J. Selva Arnold Reynaldi Hyon-Xhi Tan Wen Shi Lee Kathleen M. Wragg Hannah G. Kelly Robyn Esterbauer Samantha K. Davis Helen E. Kent Francesca L. Mordant Timothy E. Schlub David L. Gordon David S. Khoury Kanta Subbarao Deborah Cromer Tom P. Gordon Amy W. Chung Miles P. Davenport Stephen J. Kent |
| author_sort |
Adam K. Wheatley |
| title |
Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19 |
| title_short |
Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19 |
| title_full |
Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19 |
| title_fullStr |
Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19 |
| title_full_unstemmed |
Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19 |
| title_sort |
evolution of immune responses to sars-cov-2 in mild-moderate covid-19 |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e4e8f1c116754d5288a334fd4274b5ac |
| work_keys_str_mv |
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| _version_ |
1718391578930708480 |