A small molecule inhibitor of Rheb selectively targets mTORC1 signaling

Aberrant mTORC1 signaling is linked to several chronic diseases. Here, the authors develop a small molecule inhibitor that binds the small G-protein Rheb and selectively blocks mTORC1 signaling, holding potential for therapeutic applications.

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Autores principales:	Sarah J. Mahoney, Sridhar Narayan, Lisa Molz, Lauren A. Berstler, Seong A. Kang, George P. Vlasuk, Eddine Saiah
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4e93d6c676242c793f6e0e9b9280186
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spelling	oai:doaj.org-article:e4e93d6c676242c793f6e0e9b92801862021-12-02T16:49:51ZA small molecule inhibitor of Rheb selectively targets mTORC1 signaling10.1038/s41467-018-03035-z2041-1723https://doaj.org/article/e4e93d6c676242c793f6e0e9b92801862018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03035-zhttps://doaj.org/toc/2041-1723Aberrant mTORC1 signaling is linked to several chronic diseases. Here, the authors develop a small molecule inhibitor that binds the small G-protein Rheb and selectively blocks mTORC1 signaling, holding potential for therapeutic applications.Sarah J. MahoneySridhar NarayanLisa MolzLauren A. BerstlerSeong A. KangGeorge P. VlasukEddine SaiahNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah J. Mahoney Sridhar Narayan Lisa Molz Lauren A. Berstler Seong A. Kang George P. Vlasuk Eddine Saiah A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
description	Aberrant mTORC1 signaling is linked to several chronic diseases. Here, the authors develop a small molecule inhibitor that binds the small G-protein Rheb and selectively blocks mTORC1 signaling, holding potential for therapeutic applications.
format	article
author	Sarah J. Mahoney Sridhar Narayan Lisa Molz Lauren A. Berstler Seong A. Kang George P. Vlasuk Eddine Saiah
author_facet	Sarah J. Mahoney Sridhar Narayan Lisa Molz Lauren A. Berstler Seong A. Kang George P. Vlasuk Eddine Saiah
author_sort	Sarah J. Mahoney
title	A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
title_short	A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
title_full	A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
title_fullStr	A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
title_full_unstemmed	A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
title_sort	small molecule inhibitor of rheb selectively targets mtorc1 signaling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e4e93d6c676242c793f6e0e9b9280186
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A small molecule inhibitor of Rheb selectively targets mTORC1 signaling

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