Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions

Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions

Abstract Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O2 environments, elevated rates of glycolysis support critical cellular mechanisms such as cell survival. The purpose of this study was to analyze the contribut...

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Main Authors: Manuel J. Del Rey, Álvaro Valín, Alicia Usategui, Carmen M. García-Herrero, María Sánchez-Aragó, José M. Cuezva, María Galindo, Beatriz Bravo, Juan D. Cañete, Francisco J. Blanco, Gabriel Criado, José L. Pablos
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/e4ee554040b04e408dfa0f0ad44bfcfc
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