Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions

Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions

Abstract Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O2 environments, elevated rates of glycolysis support critical cellular mechanisms such as cell survival. The purpose of this study was to analyze the contribut...

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Détails bibliographiques
Auteurs principaux: Manuel J. Del Rey, Álvaro Valín, Alicia Usategui, Carmen M. García-Herrero, María Sánchez-Aragó, José M. Cuezva, María Galindo, Beatriz Bravo, Juan D. Cañete, Francisco J. Blanco, Gabriel Criado, José L. Pablos
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/e4ee554040b04e408dfa0f0ad44bfcfc
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Internet

https://doaj.org/article/e4ee554040b04e408dfa0f0ad44bfcfc

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