Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling
The inter- and intra-tumor heterogeneity of metastatic prostate cancer (mPC) is underexplored. Here the authors use Digital Spatial Profiling to study gene and protein expression heterogeneity in 27 mPC patients, finding variation in associated pathways and potential immunotherapy targets.
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Nature Portfolio
2021
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oai:doaj.org-article:e4f2a14a1c564697b67f91b5bef0c54e2021-12-02T13:14:59ZInter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling10.1038/s41467-021-21615-42041-1723https://doaj.org/article/e4f2a14a1c564697b67f91b5bef0c54e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21615-4https://doaj.org/toc/2041-1723The inter- and intra-tumor heterogeneity of metastatic prostate cancer (mPC) is underexplored. Here the authors use Digital Spatial Profiling to study gene and protein expression heterogeneity in 27 mPC patients, finding variation in associated pathways and potential immunotherapy targets.Lauren BradyMichelle KrinerIlsa ColemanColm MorrisseyMartine RoudierLawrence D. TrueRoman GulatiStephen R. PlymateZoey ZhouBrian BirdittRhonda MeredithGary GeissMargaret HoangJoseph BeechemPeter S. NelsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Lauren Brady Michelle Kriner Ilsa Coleman Colm Morrissey Martine Roudier Lawrence D. True Roman Gulati Stephen R. Plymate Zoey Zhou Brian Birditt Rhonda Meredith Gary Geiss Margaret Hoang Joseph Beechem Peter S. Nelson Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling |
| description |
The inter- and intra-tumor heterogeneity of metastatic prostate cancer (mPC) is underexplored. Here the authors use Digital Spatial Profiling to study gene and protein expression heterogeneity in 27 mPC patients, finding variation in associated pathways and potential immunotherapy targets. |
| format |
article |
| author |
Lauren Brady Michelle Kriner Ilsa Coleman Colm Morrissey Martine Roudier Lawrence D. True Roman Gulati Stephen R. Plymate Zoey Zhou Brian Birditt Rhonda Meredith Gary Geiss Margaret Hoang Joseph Beechem Peter S. Nelson |
| author_facet |
Lauren Brady Michelle Kriner Ilsa Coleman Colm Morrissey Martine Roudier Lawrence D. True Roman Gulati Stephen R. Plymate Zoey Zhou Brian Birditt Rhonda Meredith Gary Geiss Margaret Hoang Joseph Beechem Peter S. Nelson |
| author_sort |
Lauren Brady |
| title |
Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling |
| title_short |
Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling |
| title_full |
Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling |
| title_fullStr |
Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling |
| title_full_unstemmed |
Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling |
| title_sort |
inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e4f2a14a1c564697b67f91b5bef0c54e |
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