Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling
The inter- and intra-tumor heterogeneity of metastatic prostate cancer (mPC) is underexplored. Here the authors use Digital Spatial Profiling to study gene and protein expression heterogeneity in 27 mPC patients, finding variation in associated pathways and potential immunotherapy targets.
Guardado en:
Autores principales: | Lauren Brady, Michelle Kriner, Ilsa Coleman, Colm Morrissey, Martine Roudier, Lawrence D. True, Roman Gulati, Stephen R. Plymate, Zoey Zhou, Brian Birditt, Rhonda Meredith, Gary Geiss, Margaret Hoang, Joseph Beechem, Peter S. Nelson |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/e4f2a14a1c564697b67f91b5bef0c54e |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Intra-Tumoral Pharmacokinetics of Pazopanib in Combination with Radiotherapy in Patients with Non-Metastatic Soft-Tissue Sarcoma
por: Laura Molenaar-Kuijsten, et al.
Publicado: (2021) -
Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer
por: Christine Henzler, et al.
Publicado: (2016) -
Single-cell RNA transcriptome reveals the intra-tumoral heterogeneity and regulators underlying tumor progression in metastatic pancreatic ductal adenocarcinoma
por: Qianhui Xu, et al.
Publicado: (2021) -
Intra-emprendizaje
por: Irizar, Iñazio
Publicado: (2008) -
Perceptions of Intra-Uterine Device Users in Mirebalais, Haiti: A Mixed Methods Study
por: Marie Boller, et al.
Publicado: (2018)