Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?

Danny Moore, Alon Harris, Darrell WuDunn, Nisha Kheradiya, Brent Siesky1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USAAbstract: Primary open angle glaucoma (OAG) is a multifactorial optic neuropathy characterized by progressive retinal ganglion cell death a...

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Autores principales:	Danny Moore, Alon Harris, Darrell WuDunn, Nisha Kheradiya, Brent Siesky
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e4f2e1f70144440095a786b633e317df
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spelling	oai:doaj.org-article:e4f2e1f70144440095a786b633e317df2021-12-02T02:48:04ZDysfunctional regulation of ocular blood flow: A risk factor for glaucoma?1177-54671177-5483https://doaj.org/article/e4f2e1f70144440095a786b633e317df2008-04-01T00:00:00Zhttp://www.dovepress.com/dysfunctional-regulation-of-ocular-blood-flow-a-risk-factor-for-glauco-a411https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Danny Moore, Alon Harris, Darrell WuDunn, Nisha Kheradiya, Brent Siesky1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USAAbstract: Primary open angle glaucoma (OAG) is a multifactorial optic neuropathy characterized by progressive retinal ganglion cell death and associated visual field loss. OAG is an emerging disease with increasing costs and negative outcomes, yet its fundamental pathophysiology remains largely undetermined. A major treatable risk factor for glaucoma is elevated intraocular pressure (IOP). Despite the medical lowering of IOP, however, some glaucoma patients continue to experience disease progression and subsequent irreversible vision loss. The scientific community continues to accrue evidence suggesting that alterations in ocular blood flow play a prominent role in OAG disease processes. This article develops the thesis that dysfunctional regulation of ocular blood flow may contribute to glaucomatous optic neuropathy. Evidence suggests that impaired vascular autoregulation renders the optic nerve head susceptible to decreases in ocular perfusion pressure, increases in IOP, and/or increased local metabolic demands. Ischemic damage, which likely contributes to further impairment in autoregulation, results in changes to the optic nerve head consistent with glaucoma. Included in this review are discussions of conditions thought to contribute to vascular regulatory dysfunction in OAG, including atherosclerosis, vasospasm, and endothelial dysfunction.Keywords: glaucoma, autoregulation, blood flow, atherosclerosis, vasospasm, endothelial dysfunction Danny MooreAlon HarrisDarrell WuDunnNisha KheradiyaBrent SieskyDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 4, Pp 849-861 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Danny Moore Alon Harris Darrell WuDunn Nisha Kheradiya Brent Siesky Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?
description	Danny Moore, Alon Harris, Darrell WuDunn, Nisha Kheradiya, Brent Siesky1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USAAbstract: Primary open angle glaucoma (OAG) is a multifactorial optic neuropathy characterized by progressive retinal ganglion cell death and associated visual field loss. OAG is an emerging disease with increasing costs and negative outcomes, yet its fundamental pathophysiology remains largely undetermined. A major treatable risk factor for glaucoma is elevated intraocular pressure (IOP). Despite the medical lowering of IOP, however, some glaucoma patients continue to experience disease progression and subsequent irreversible vision loss. The scientific community continues to accrue evidence suggesting that alterations in ocular blood flow play a prominent role in OAG disease processes. This article develops the thesis that dysfunctional regulation of ocular blood flow may contribute to glaucomatous optic neuropathy. Evidence suggests that impaired vascular autoregulation renders the optic nerve head susceptible to decreases in ocular perfusion pressure, increases in IOP, and/or increased local metabolic demands. Ischemic damage, which likely contributes to further impairment in autoregulation, results in changes to the optic nerve head consistent with glaucoma. Included in this review are discussions of conditions thought to contribute to vascular regulatory dysfunction in OAG, including atherosclerosis, vasospasm, and endothelial dysfunction.Keywords: glaucoma, autoregulation, blood flow, atherosclerosis, vasospasm, endothelial dysfunction
format	article
author	Danny Moore Alon Harris Darrell WuDunn Nisha Kheradiya Brent Siesky
author_facet	Danny Moore Alon Harris Darrell WuDunn Nisha Kheradiya Brent Siesky
author_sort	Danny Moore
title	Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?
title_short	Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?
title_full	Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?
title_fullStr	Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?
title_full_unstemmed	Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?
title_sort	dysfunctional regulation of ocular blood flow: a risk factor for glaucoma?
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/e4f2e1f70144440095a786b633e317df
work_keys_str_mv	AT dannymoore dysfunctionalregulationofocularbloodflowariskfactorforglaucoma AT alonharris dysfunctionalregulationofocularbloodflowariskfactorforglaucoma AT darrellwudunn dysfunctionalregulationofocularbloodflowariskfactorforglaucoma AT nishakheradiya dysfunctionalregulationofocularbloodflowariskfactorforglaucoma AT brentsiesky dysfunctionalregulationofocularbloodflowariskfactorforglaucoma
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Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?

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