The Relationship Between Circulating Bone Morphogenetic Protein-4 and Inflammation Cytokines in Patients Undergoing Thoracic Surgery: A Prospective Randomized Study

Xu Zhao,1,&ast; Jitao Zhang,1,&ast; Wenjuan Zhang,2 Ruping Dai,1 Junmei Xu,1 Zhijian Li,1 Lin Yang1 1Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China; 2Department of Laboratory Medicine, The Second Xiangy...

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Autores principales:	Zhao X, Zhang J, Zhang W, Dai R, Xu J, Li Z, Yang L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	bone morphogenetic protein-4 noggin inflammation non-steroidal anti-inflammatory drugs perioperative cyclooxygenase-ii Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e4f4381bebfc4f4dbfc83cd29c08ad68
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spelling	oai:doaj.org-article:e4f4381bebfc4f4dbfc83cd29c08ad682021-12-02T15:11:07ZThe Relationship Between Circulating Bone Morphogenetic Protein-4 and Inflammation Cytokines in Patients Undergoing Thoracic Surgery: A Prospective Randomized Study1178-7031https://doaj.org/article/e4f4381bebfc4f4dbfc83cd29c08ad682021-08-01T00:00:00Zhttps://www.dovepress.com/the-relationship-between-circulating-bone-morphogenetic-protein-4-and--peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Xu Zhao,1,&ast; Jitao Zhang,1,&ast; Wenjuan Zhang,2 Ruping Dai,1 Junmei Xu,1 Zhijian Li,1 Lin Yang1 1Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China; 2Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lin Yang; Zhijian LiDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of ChinaFax +86 73185295970; Fax +86 73185295970Email linyang@csu.edu.cn; lizhijian@csu.edu.cnBackground: Bone morphogenetic protein-4 (BMP4) has been identified as an inflammation regulator in the diseases of arteries and other organs. However, the relationship between circulating BMP4 and perioperative inflammation remains unclear.Patients and Methods: Forty patients undergoing lobectomy were randomly allocated into the Control group (not receiving flurbiprofen) and the Flurb group (received 100mg flurbiprofen during surgery). Arterial blood was obtained before surgery (T1), at the end of surgery (T2), and 24 hours after surgery (T3) to test the plasma concentrations of BMP4, its antagonist Noggin, interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), and IL-10. The relationship between BMP4 and other variables and the effects of flurbiprofen on BMP4 changes were investigated.Results: A total of 35 patients were included. Circulating BMP4 was positively correlated with IL-1β (P< 0.01, r=0.575) and TNF-α (P< 0.01, r=0.491), negatively correlated with IL-10 (P< 0.01, r=− 0.675), but not correlated with Noggin. The plasma concentrations of BMP4, IL-1β, and TNF-α increased at T2 (P< 0.01, compared with T1) and decreased at T3 (P< 0.05, compared with T2). BMP4 concentrations at T3 were significantly higher than at T1 in the Control group (P< 0.05), while showing no significant difference in the Flurb group. However, in the Flurb group, the relative changes of BMP4 and IL-1β at T2 and T3 were significantly lower than those in the Control group.Conclusion: Circulating BMP4 was elevated during surgery and highly correlated with inflammation cytokines. The elevation of BMP4 and inflammatory cytokines could be alleviated by flurbiprofen, indicating that BMP4 may exert pro-inflammatory properties via cyclooxygenase-II signaling pathways.Keywords: bone morphogenetic protein-4, Noggin, inflammation, non-steroidal anti-inflammatory drugs, perioperative, cyclooxygenase-IIZhao XZhang JZhang WDai RXu JLi ZYang LDove Medical Pressarticlebone morphogenetic protein-4noggininflammationnon-steroidal anti-inflammatory drugsperioperativecyclooxygenase-iiPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 4069-4077 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone morphogenetic protein-4 noggin inflammation non-steroidal anti-inflammatory drugs perioperative cyclooxygenase-ii Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	bone morphogenetic protein-4 noggin inflammation non-steroidal anti-inflammatory drugs perioperative cyclooxygenase-ii Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Zhao X Zhang J Zhang W Dai R Xu J Li Z Yang L The Relationship Between Circulating Bone Morphogenetic Protein-4 and Inflammation Cytokines in Patients Undergoing Thoracic Surgery: A Prospective Randomized Study
description	Xu Zhao,1,&ast; Jitao Zhang,1,&ast; Wenjuan Zhang,2 Ruping Dai,1 Junmei Xu,1 Zhijian Li,1 Lin Yang1 1Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China; 2Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lin Yang; Zhijian LiDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of ChinaFax +86 73185295970; Fax +86 73185295970Email linyang@csu.edu.cn; lizhijian@csu.edu.cnBackground: Bone morphogenetic protein-4 (BMP4) has been identified as an inflammation regulator in the diseases of arteries and other organs. However, the relationship between circulating BMP4 and perioperative inflammation remains unclear.Patients and Methods: Forty patients undergoing lobectomy were randomly allocated into the Control group (not receiving flurbiprofen) and the Flurb group (received 100mg flurbiprofen during surgery). Arterial blood was obtained before surgery (T1), at the end of surgery (T2), and 24 hours after surgery (T3) to test the plasma concentrations of BMP4, its antagonist Noggin, interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), and IL-10. The relationship between BMP4 and other variables and the effects of flurbiprofen on BMP4 changes were investigated.Results: A total of 35 patients were included. Circulating BMP4 was positively correlated with IL-1β (P< 0.01, r=0.575) and TNF-α (P< 0.01, r=0.491), negatively correlated with IL-10 (P< 0.01, r=− 0.675), but not correlated with Noggin. The plasma concentrations of BMP4, IL-1β, and TNF-α increased at T2 (P< 0.01, compared with T1) and decreased at T3 (P< 0.05, compared with T2). BMP4 concentrations at T3 were significantly higher than at T1 in the Control group (P< 0.05), while showing no significant difference in the Flurb group. However, in the Flurb group, the relative changes of BMP4 and IL-1β at T2 and T3 were significantly lower than those in the Control group.Conclusion: Circulating BMP4 was elevated during surgery and highly correlated with inflammation cytokines. The elevation of BMP4 and inflammatory cytokines could be alleviated by flurbiprofen, indicating that BMP4 may exert pro-inflammatory properties via cyclooxygenase-II signaling pathways.Keywords: bone morphogenetic protein-4, Noggin, inflammation, non-steroidal anti-inflammatory drugs, perioperative, cyclooxygenase-II
format	article
author	Zhao X Zhang J Zhang W Dai R Xu J Li Z Yang L
author_facet	Zhao X Zhang J Zhang W Dai R Xu J Li Z Yang L
author_sort	Zhao X
title	The Relationship Between Circulating Bone Morphogenetic Protein-4 and Inflammation Cytokines in Patients Undergoing Thoracic Surgery: A Prospective Randomized Study
title_short	The Relationship Between Circulating Bone Morphogenetic Protein-4 and Inflammation Cytokines in Patients Undergoing Thoracic Surgery: A Prospective Randomized Study
title_full	The Relationship Between Circulating Bone Morphogenetic Protein-4 and Inflammation Cytokines in Patients Undergoing Thoracic Surgery: A Prospective Randomized Study
title_fullStr	The Relationship Between Circulating Bone Morphogenetic Protein-4 and Inflammation Cytokines in Patients Undergoing Thoracic Surgery: A Prospective Randomized Study
title_full_unstemmed	The Relationship Between Circulating Bone Morphogenetic Protein-4 and Inflammation Cytokines in Patients Undergoing Thoracic Surgery: A Prospective Randomized Study
title_sort	relationship between circulating bone morphogenetic protein-4 and inflammation cytokines in patients undergoing thoracic surgery: a prospective randomized study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e4f4381bebfc4f4dbfc83cd29c08ad68
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The Relationship Between Circulating Bone Morphogenetic Protein-4 and Inflammation Cytokines in Patients Undergoing Thoracic Surgery: A Prospective Randomized Study

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