Ultradian rhythms in heart rate variability and distal body temperature anticipate onset of the luteinizing hormone surge

Abstract The menstrual cycle is characterized by predictable patterns of physiological change across timescales. Although patterns of reproductive hormones across the menstrual cycle, particularly ultradian rhythms, are well described, monitoring these measures repeatedly to predict the preovulatory...

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Autores principales:	Azure D. Grant, Mark Newman, Lance J. Kriegsfeld
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4f4d150954c4e23abe39adecffbb7a5
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spelling	oai:doaj.org-article:e4f4d150954c4e23abe39adecffbb7a52021-12-02T16:08:47ZUltradian rhythms in heart rate variability and distal body temperature anticipate onset of the luteinizing hormone surge10.1038/s41598-020-76236-62045-2322https://doaj.org/article/e4f4d150954c4e23abe39adecffbb7a52020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-76236-6https://doaj.org/toc/2045-2322Abstract The menstrual cycle is characterized by predictable patterns of physiological change across timescales. Although patterns of reproductive hormones across the menstrual cycle, particularly ultradian rhythms, are well described, monitoring these measures repeatedly to predict the preovulatory luteinizing hormone (LH) surge is not practical. In the present study, we explored whether non-invasive measures coupled to the reproductive system: high frequency distal body temperature (DBT), sleeping heart rate (HR), sleeping heart rate variability (HRV), and sleep timing, could be used to anticipate the preovulatory LH surge in women. To test this possibility, we used signal processing to examine these measures in 45 premenopausal and 10 perimenopausal cycles alongside dates of supra-surge threshold LH and menstruation. Additionally, urinary estradiol and progesterone metabolites were measured daily surrounding the LH surge in 20 cycles. Wavelet analysis revealed a consistent pattern of DBT and HRV ultradian rhythm (2–5 h) power that uniquely enabled anticipation of the LH surge at least 2 days prior to its onset in 100% of individuals. Together, the present findings reveal fluctuations in distal body temperature and heart rate variability that consistently anticipate the LH surge, suggesting that automated ultradian rhythm monitoring may provide a novel and convenient method for non-invasive fertility assessment.Azure D. GrantMark NewmanLance J. KriegsfeldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Azure D. Grant Mark Newman Lance J. Kriegsfeld Ultradian rhythms in heart rate variability and distal body temperature anticipate onset of the luteinizing hormone surge
description	Abstract The menstrual cycle is characterized by predictable patterns of physiological change across timescales. Although patterns of reproductive hormones across the menstrual cycle, particularly ultradian rhythms, are well described, monitoring these measures repeatedly to predict the preovulatory luteinizing hormone (LH) surge is not practical. In the present study, we explored whether non-invasive measures coupled to the reproductive system: high frequency distal body temperature (DBT), sleeping heart rate (HR), sleeping heart rate variability (HRV), and sleep timing, could be used to anticipate the preovulatory LH surge in women. To test this possibility, we used signal processing to examine these measures in 45 premenopausal and 10 perimenopausal cycles alongside dates of supra-surge threshold LH and menstruation. Additionally, urinary estradiol and progesterone metabolites were measured daily surrounding the LH surge in 20 cycles. Wavelet analysis revealed a consistent pattern of DBT and HRV ultradian rhythm (2–5 h) power that uniquely enabled anticipation of the LH surge at least 2 days prior to its onset in 100% of individuals. Together, the present findings reveal fluctuations in distal body temperature and heart rate variability that consistently anticipate the LH surge, suggesting that automated ultradian rhythm monitoring may provide a novel and convenient method for non-invasive fertility assessment.
format	article
author	Azure D. Grant Mark Newman Lance J. Kriegsfeld
author_facet	Azure D. Grant Mark Newman Lance J. Kriegsfeld
author_sort	Azure D. Grant
title	Ultradian rhythms in heart rate variability and distal body temperature anticipate onset of the luteinizing hormone surge
title_short	Ultradian rhythms in heart rate variability and distal body temperature anticipate onset of the luteinizing hormone surge
title_full	Ultradian rhythms in heart rate variability and distal body temperature anticipate onset of the luteinizing hormone surge
title_fullStr	Ultradian rhythms in heart rate variability and distal body temperature anticipate onset of the luteinizing hormone surge
title_full_unstemmed	Ultradian rhythms in heart rate variability and distal body temperature anticipate onset of the luteinizing hormone surge
title_sort	ultradian rhythms in heart rate variability and distal body temperature anticipate onset of the luteinizing hormone surge
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e4f4d150954c4e23abe39adecffbb7a5
work_keys_str_mv	AT azuredgrant ultradianrhythmsinheartratevariabilityanddistalbodytemperatureanticipateonsetoftheluteinizinghormonesurge AT marknewman ultradianrhythmsinheartratevariabilityanddistalbodytemperatureanticipateonsetoftheluteinizinghormonesurge AT lancejkriegsfeld ultradianrhythmsinheartratevariabilityanddistalbodytemperatureanticipateonsetoftheluteinizinghormonesurge
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Ultradian rhythms in heart rate variability and distal body temperature anticipate onset of the luteinizing hormone surge

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