Microbiome dysbiosis in lung cancer: from composition to therapy

Abstract The correlations between microbiota dysbiosis and cancer have gained extensive attention and been widely explored. As a leading cancer diagnosis worldwide, lung cancer poses a great threat to human health. The healthy human lungs are consistently exposed to external environment and harbor a...

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Autores principales:	Ning-Ning Liu, Qiang Ma, Yang Ge, Cheng-Xiang Yi, Lu-Qi Wei, Jing-Cong Tan, Qiao Chu, Jing-Quan Li, Peng Zhang, Hui Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e4f4d1a8db154fe3bbc82672755c4f4c
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spelling	oai:doaj.org-article:e4f4d1a8db154fe3bbc82672755c4f4c2021-12-02T14:22:18ZMicrobiome dysbiosis in lung cancer: from composition to therapy10.1038/s41698-020-00138-z2397-768Xhttps://doaj.org/article/e4f4d1a8db154fe3bbc82672755c4f4c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41698-020-00138-zhttps://doaj.org/toc/2397-768XAbstract The correlations between microbiota dysbiosis and cancer have gained extensive attention and been widely explored. As a leading cancer diagnosis worldwide, lung cancer poses a great threat to human health. The healthy human lungs are consistently exposed to external environment and harbor a specific pattern of microbiota, sharing many key pathological and physiological characteristics with the intestinal tract. Although previous findings uncovered the critical roles of microbiota in tumorigenesis and response to anticancer therapy, most of them were focused on the intestinal microbiota rather than lung microbiota. Notably, the considerable functions of microbiota in maintaining lung homeostasis should not be neglected as the microbiome dysbiosis may promote tumor development and progression through production of cytokines and toxins and multiple other pathways. Despite the fact that increasing studies have revealed the effect of microbiome on the induction of lung cancer and different disease status, the underlying mechanisms and potential therapeutic strategies remained unclear. Herein, we summarized the recent progresses about microbiome in lung cancer and further discussed the role of microbial communities in promoting lung cancer progression and the current status of therapeutic approaches targeting microbiome to alleviate and even cure lung cancer.Ning-Ning LiuQiang MaYang GeCheng-Xiang YiLu-Qi WeiJing-Cong TanQiao ChuJing-Quan LiPeng ZhangHui WangNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 4, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ning-Ning Liu Qiang Ma Yang Ge Cheng-Xiang Yi Lu-Qi Wei Jing-Cong Tan Qiao Chu Jing-Quan Li Peng Zhang Hui Wang Microbiome dysbiosis in lung cancer: from composition to therapy
description	Abstract The correlations between microbiota dysbiosis and cancer have gained extensive attention and been widely explored. As a leading cancer diagnosis worldwide, lung cancer poses a great threat to human health. The healthy human lungs are consistently exposed to external environment and harbor a specific pattern of microbiota, sharing many key pathological and physiological characteristics with the intestinal tract. Although previous findings uncovered the critical roles of microbiota in tumorigenesis and response to anticancer therapy, most of them were focused on the intestinal microbiota rather than lung microbiota. Notably, the considerable functions of microbiota in maintaining lung homeostasis should not be neglected as the microbiome dysbiosis may promote tumor development and progression through production of cytokines and toxins and multiple other pathways. Despite the fact that increasing studies have revealed the effect of microbiome on the induction of lung cancer and different disease status, the underlying mechanisms and potential therapeutic strategies remained unclear. Herein, we summarized the recent progresses about microbiome in lung cancer and further discussed the role of microbial communities in promoting lung cancer progression and the current status of therapeutic approaches targeting microbiome to alleviate and even cure lung cancer.
format	article
author	Ning-Ning Liu Qiang Ma Yang Ge Cheng-Xiang Yi Lu-Qi Wei Jing-Cong Tan Qiao Chu Jing-Quan Li Peng Zhang Hui Wang
author_facet	Ning-Ning Liu Qiang Ma Yang Ge Cheng-Xiang Yi Lu-Qi Wei Jing-Cong Tan Qiao Chu Jing-Quan Li Peng Zhang Hui Wang
author_sort	Ning-Ning Liu
title	Microbiome dysbiosis in lung cancer: from composition to therapy
title_short	Microbiome dysbiosis in lung cancer: from composition to therapy
title_full	Microbiome dysbiosis in lung cancer: from composition to therapy
title_fullStr	Microbiome dysbiosis in lung cancer: from composition to therapy
title_full_unstemmed	Microbiome dysbiosis in lung cancer: from composition to therapy
title_sort	microbiome dysbiosis in lung cancer: from composition to therapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e4f4d1a8db154fe3bbc82672755c4f4c
work_keys_str_mv	AT ningningliu microbiomedysbiosisinlungcancerfromcompositiontotherapy AT qiangma microbiomedysbiosisinlungcancerfromcompositiontotherapy AT yangge microbiomedysbiosisinlungcancerfromcompositiontotherapy AT chengxiangyi microbiomedysbiosisinlungcancerfromcompositiontotherapy AT luqiwei microbiomedysbiosisinlungcancerfromcompositiontotherapy AT jingcongtan microbiomedysbiosisinlungcancerfromcompositiontotherapy AT qiaochu microbiomedysbiosisinlungcancerfromcompositiontotherapy AT jingquanli microbiomedysbiosisinlungcancerfromcompositiontotherapy AT pengzhang microbiomedysbiosisinlungcancerfromcompositiontotherapy AT huiwang microbiomedysbiosisinlungcancerfromcompositiontotherapy
_version_	1718391521831550976

Microbiome dysbiosis in lung cancer: from composition to therapy

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