Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans.

The dauer larva is a specialized dispersal stage in the nematode Caenorhabditis elegans that allows the animal to survive starvation for an extended period of time. The dauer does not feed, but uses chemosensation to identify new food sources and to determine whether to resume reproductive growth. B...

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Autores principales:	Tiffany K Kaul, Pedro Reis Rodrigues, Ifedayo V Ogungbe, Pankaj Kapahi, Matthew S Gill
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4f62b0bdd6a48dfb7d89358c5e551d9
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spelling	oai:doaj.org-article:e4f62b0bdd6a48dfb7d89358c5e551d92021-11-18T08:35:51ZBacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans.1932-620310.1371/journal.pone.0086979https://doaj.org/article/e4f62b0bdd6a48dfb7d89358c5e551d92014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24475206/?tool=EBIhttps://doaj.org/toc/1932-6203The dauer larva is a specialized dispersal stage in the nematode Caenorhabditis elegans that allows the animal to survive starvation for an extended period of time. The dauer does not feed, but uses chemosensation to identify new food sources and to determine whether to resume reproductive growth. Bacteria produce food signals that promote recovery of the dauer larva, but the chemical identities of these signals remain poorly defined. We find that bacterial fatty acids in the environment augment recovery from the dauer stage under permissive conditions. The effect of increased fatty acids on different dauer constitutive mutants indicates a role for insulin peptide secretion in coordinating recovery from the dauer stage in response to fatty acids. These data suggest that worms can sense the presence of fatty acids in the environment and that elevated levels can promote recovery from dauer arrest. This may be important in the natural environment where the dauer larva needs to determine whether the environment is appropriate to support reproductive growth following dauer exit.Tiffany K KaulPedro Reis RodriguesIfedayo V OgungbePankaj KapahiMatthew S GillPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e86979 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tiffany K Kaul Pedro Reis Rodrigues Ifedayo V Ogungbe Pankaj Kapahi Matthew S Gill Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans.
description	The dauer larva is a specialized dispersal stage in the nematode Caenorhabditis elegans that allows the animal to survive starvation for an extended period of time. The dauer does not feed, but uses chemosensation to identify new food sources and to determine whether to resume reproductive growth. Bacteria produce food signals that promote recovery of the dauer larva, but the chemical identities of these signals remain poorly defined. We find that bacterial fatty acids in the environment augment recovery from the dauer stage under permissive conditions. The effect of increased fatty acids on different dauer constitutive mutants indicates a role for insulin peptide secretion in coordinating recovery from the dauer stage in response to fatty acids. These data suggest that worms can sense the presence of fatty acids in the environment and that elevated levels can promote recovery from dauer arrest. This may be important in the natural environment where the dauer larva needs to determine whether the environment is appropriate to support reproductive growth following dauer exit.
format	article
author	Tiffany K Kaul Pedro Reis Rodrigues Ifedayo V Ogungbe Pankaj Kapahi Matthew S Gill
author_facet	Tiffany K Kaul Pedro Reis Rodrigues Ifedayo V Ogungbe Pankaj Kapahi Matthew S Gill
author_sort	Tiffany K Kaul
title	Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans.
title_short	Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans.
title_full	Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans.
title_fullStr	Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans.
title_full_unstemmed	Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans.
title_sort	bacterial fatty acids enhance recovery from the dauer larva in caenorhabditis elegans.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/e4f62b0bdd6a48dfb7d89358c5e551d9
work_keys_str_mv	AT tiffanykkaul bacterialfattyacidsenhancerecoveryfromthedauerlarvaincaenorhabditiselegans AT pedroreisrodrigues bacterialfattyacidsenhancerecoveryfromthedauerlarvaincaenorhabditiselegans AT ifedayovogungbe bacterialfattyacidsenhancerecoveryfromthedauerlarvaincaenorhabditiselegans AT pankajkapahi bacterialfattyacidsenhancerecoveryfromthedauerlarvaincaenorhabditiselegans AT matthewsgill bacterialfattyacidsenhancerecoveryfromthedauerlarvaincaenorhabditiselegans
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Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans.

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