Incidence of new-onset diabetes among sudanese renal transplant patients using different immunosuppressive regimens: A retrospective study

Background: New onset diabetes after renal transplant (NODAT) is a serious complication of therapy with immunosuppressive drugs. The aim of this study was to estimate the incidence of NODAT and its association with immunosuppressant regimens within 6 months of the administration. Methodology: A desc...

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Autores principales:	Alaa Mohammedazeem Elzain, Safaa Badi, Bashir Alsiddig Yousef, Habab Khalid Elkheir
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	immunosuppressive regimens incidence new-onset diabetes renal transplantation Medicine R Nursing RT1-120
Acceso en línea:	https://doaj.org/article/e4f8520dfd754aa7a43f227f58c87e0f
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spelling	oai:doaj.org-article:e4f8520dfd754aa7a43f227f58c87e0f2021-11-12T10:09:47ZIncidence of new-onset diabetes among sudanese renal transplant patients using different immunosuppressive regimens: A retrospective study2348-33342348-506X10.4103/cjhr.cjhr_45_20https://doaj.org/article/e4f8520dfd754aa7a43f227f58c87e0f2021-01-01T00:00:00Zhttp://www.cjhr.org/article.asp?issn=2348-3334;year=2021;volume=8;issue=2;spage=110;epage=116;aulast=Elzainhttps://doaj.org/toc/2348-3334https://doaj.org/toc/2348-506XBackground: New onset diabetes after renal transplant (NODAT) is a serious complication of therapy with immunosuppressive drugs. The aim of this study was to estimate the incidence of NODAT and its association with immunosuppressant regimens within 6 months of the administration. Methodology: A descriptive retrospective case finding hospital-based study, conducted in the department of nephrology at Ahmed Gasim Hospital from January to September 2017, on patients who underwent renal transplantation between June 2015 and June 2016. The data were collected using a structured checklist. The collected data were analyzed by the Statistical Package for Social Sciences (SPSS). Results: A total of 110 patients were included, the majority of studied patients were males (71.8%) and in the age group of 20–40 years (50.9%). The most commonly prescribed immunosuppressant regimen was regimen, which consists of methylprednisolone as induction therapy and tacrolimus + azathioprine + prednisolone as maintenance therapy. Regarding the adverse effects, 11 (10%) of them developed NODAT throughout 6 months after transplantation. However, no significant association was found between the postulated risk factors and the incidence of NODAT. Conclusion: The incidence of NODAT was 10% throughout 6 months after transplantation. Correlations between sociodemographic characteristics, immunosuppressant regimens, episodes of rejection with the incidence of NODAT were found statistically insignificant.Alaa Mohammedazeem ElzainSafaa BadiBashir Alsiddig YousefHabab Khalid ElkheirWolters Kluwer Medknow Publicationsarticle immunosuppressive regimensincidencenew-onset diabetesrenal transplantation MedicineRNursingRT1-120ENCHRISMED Journal of Health and Research, Vol 8, Iss 2, Pp 110-116 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunosuppressive regimens incidence new-onset diabetes renal transplantation Medicine R Nursing RT1-120
spellingShingle	immunosuppressive regimens incidence new-onset diabetes renal transplantation Medicine R Nursing RT1-120 Alaa Mohammedazeem Elzain Safaa Badi Bashir Alsiddig Yousef Habab Khalid Elkheir Incidence of new-onset diabetes among sudanese renal transplant patients using different immunosuppressive regimens: A retrospective study
description	Background: New onset diabetes after renal transplant (NODAT) is a serious complication of therapy with immunosuppressive drugs. The aim of this study was to estimate the incidence of NODAT and its association with immunosuppressant regimens within 6 months of the administration. Methodology: A descriptive retrospective case finding hospital-based study, conducted in the department of nephrology at Ahmed Gasim Hospital from January to September 2017, on patients who underwent renal transplantation between June 2015 and June 2016. The data were collected using a structured checklist. The collected data were analyzed by the Statistical Package for Social Sciences (SPSS). Results: A total of 110 patients were included, the majority of studied patients were males (71.8%) and in the age group of 20–40 years (50.9%). The most commonly prescribed immunosuppressant regimen was regimen, which consists of methylprednisolone as induction therapy and tacrolimus + azathioprine + prednisolone as maintenance therapy. Regarding the adverse effects, 11 (10%) of them developed NODAT throughout 6 months after transplantation. However, no significant association was found between the postulated risk factors and the incidence of NODAT. Conclusion: The incidence of NODAT was 10% throughout 6 months after transplantation. Correlations between sociodemographic characteristics, immunosuppressant regimens, episodes of rejection with the incidence of NODAT were found statistically insignificant.
format	article
author	Alaa Mohammedazeem Elzain Safaa Badi Bashir Alsiddig Yousef Habab Khalid Elkheir
author_facet	Alaa Mohammedazeem Elzain Safaa Badi Bashir Alsiddig Yousef Habab Khalid Elkheir
author_sort	Alaa Mohammedazeem Elzain
title	Incidence of new-onset diabetes among sudanese renal transplant patients using different immunosuppressive regimens: A retrospective study
title_short	Incidence of new-onset diabetes among sudanese renal transplant patients using different immunosuppressive regimens: A retrospective study
title_full	Incidence of new-onset diabetes among sudanese renal transplant patients using different immunosuppressive regimens: A retrospective study
title_fullStr	Incidence of new-onset diabetes among sudanese renal transplant patients using different immunosuppressive regimens: A retrospective study
title_full_unstemmed	Incidence of new-onset diabetes among sudanese renal transplant patients using different immunosuppressive regimens: A retrospective study
title_sort	incidence of new-onset diabetes among sudanese renal transplant patients using different immunosuppressive regimens: a retrospective study
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/e4f8520dfd754aa7a43f227f58c87e0f
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Incidence of new-onset diabetes among sudanese renal transplant patients using different immunosuppressive regimens: A retrospective study

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