Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources

Background: The world has been unprecedentedly hit by a global pandemic which broke the record of deadly pandemics that faced humanity ever since its existence. Even kids are well-versed in the terminologies and basics of the SARS-CoV-2 virus and COVID-19 now. The vaccination program has been succes...

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Autores principales:	Rajeev K. Singla, Xuefei He, Hitesh Chopra, Christos Tsagkaris, Li Shen, Mohammad Amjad Kamal, Bairong Shen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	SARS-CoV-2 complementary medicine secondary metabolites polyherbal formulation intestinal microbiota pro-inflammatory markers Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e4f8a3fff44d41b9a2b5b78d3c872bbe
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spelling	oai:doaj.org-article:e4f8a3fff44d41b9a2b5b78d3c872bbe2021-12-01T23:42:33ZNatural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources1663-981210.3389/fphar.2021.758159https://doaj.org/article/e4f8a3fff44d41b9a2b5b78d3c872bbe2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.758159/fullhttps://doaj.org/toc/1663-9812Background: The world has been unprecedentedly hit by a global pandemic which broke the record of deadly pandemics that faced humanity ever since its existence. Even kids are well-versed in the terminologies and basics of the SARS-CoV-2 virus and COVID-19 now. The vaccination program has been successfully launched in various countries, given that the huge global population of concern is still far behind to be vaccinated. Furthermore, the scarcity of any potential drug against the COVID-19-causing virus forces scientists and clinicians to search for alternative and complementary medicines on a war-footing basis.Aims and Objectives: The present review aims to cover and analyze the etiology and epidemiology of COVID-19, the role of intestinal microbiota and pro-inflammatory markers, and most importantly, the natural products to combat this deadly SARS-CoV-2 virus.Methods: A primary literature search was conducted through PubMed and Google Scholar using relevant keywords. Natural products were searched from January 2020 to November 2020. No timeline limit has been imposed on the search for the biological sources of those phytochemicals. Interactive mapping has been done to analyze the multi-modal and multi-target sources.Results and Discussion: The intestinal microbiota and the pro-inflammatory markers that can serve the prognosis, diagnosis, and treatment of COVID-19 were discussed. The literature search resulted in yielding 70 phytochemicals and ten polyherbal formulations which were scientifically analyzed against the SARS-CoV-2 virus and its targets and found significant. Retrospective analyses led to provide information about 165 biological sources that can also be screened if not done earlier.Conclusion: The interactive analysis mapping of biological sources with phytochemicals and targets as well as that of phytochemical class with phytochemicals and COVID-19 targets yielded insights into the multitarget and multimodal evidence-based complementary medicines.Rajeev K. SinglaRajeev K. SinglaXuefei HeHitesh ChopraChristos TsagkarisLi ShenMohammad Amjad KamalMohammad Amjad KamalMohammad Amjad KamalBairong ShenFrontiers Media S.A.articleSARS-CoV-2complementary medicinesecondary metabolitespolyherbal formulationintestinal microbiotapro-inflammatory markersTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 complementary medicine secondary metabolites polyherbal formulation intestinal microbiota pro-inflammatory markers Therapeutics. Pharmacology RM1-950
spellingShingle	SARS-CoV-2 complementary medicine secondary metabolites polyherbal formulation intestinal microbiota pro-inflammatory markers Therapeutics. Pharmacology RM1-950 Rajeev K. Singla Rajeev K. Singla Xuefei He Hitesh Chopra Christos Tsagkaris Li Shen Mohammad Amjad Kamal Mohammad Amjad Kamal Mohammad Amjad Kamal Bairong Shen Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources
description	Background: The world has been unprecedentedly hit by a global pandemic which broke the record of deadly pandemics that faced humanity ever since its existence. Even kids are well-versed in the terminologies and basics of the SARS-CoV-2 virus and COVID-19 now. The vaccination program has been successfully launched in various countries, given that the huge global population of concern is still far behind to be vaccinated. Furthermore, the scarcity of any potential drug against the COVID-19-causing virus forces scientists and clinicians to search for alternative and complementary medicines on a war-footing basis.Aims and Objectives: The present review aims to cover and analyze the etiology and epidemiology of COVID-19, the role of intestinal microbiota and pro-inflammatory markers, and most importantly, the natural products to combat this deadly SARS-CoV-2 virus.Methods: A primary literature search was conducted through PubMed and Google Scholar using relevant keywords. Natural products were searched from January 2020 to November 2020. No timeline limit has been imposed on the search for the biological sources of those phytochemicals. Interactive mapping has been done to analyze the multi-modal and multi-target sources.Results and Discussion: The intestinal microbiota and the pro-inflammatory markers that can serve the prognosis, diagnosis, and treatment of COVID-19 were discussed. The literature search resulted in yielding 70 phytochemicals and ten polyherbal formulations which were scientifically analyzed against the SARS-CoV-2 virus and its targets and found significant. Retrospective analyses led to provide information about 165 biological sources that can also be screened if not done earlier.Conclusion: The interactive analysis mapping of biological sources with phytochemicals and targets as well as that of phytochemical class with phytochemicals and COVID-19 targets yielded insights into the multitarget and multimodal evidence-based complementary medicines.
format	article
author	Rajeev K. Singla Rajeev K. Singla Xuefei He Hitesh Chopra Christos Tsagkaris Li Shen Mohammad Amjad Kamal Mohammad Amjad Kamal Mohammad Amjad Kamal Bairong Shen
author_facet	Rajeev K. Singla Rajeev K. Singla Xuefei He Hitesh Chopra Christos Tsagkaris Li Shen Mohammad Amjad Kamal Mohammad Amjad Kamal Mohammad Amjad Kamal Bairong Shen
author_sort	Rajeev K. Singla
title	Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources
title_short	Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources
title_full	Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources
title_fullStr	Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources
title_full_unstemmed	Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources
title_sort	natural products for the prevention and control of the covid-19 pandemic: sustainable bioresources
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e4f8a3fff44d41b9a2b5b78d3c872bbe
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Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources

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