Environmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001–2002

Pyrethroid compounds are widely used in household insecticides and agricultural pesticides. Recent studies, however, report that pyrethroid exposures affect neurobehavioral function in animals and may be associated with adverse neurocognitive development in children. This study aimed to examine the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ui-Jin Kim, Myeongjin Hong, Yoon-Hyeong Choi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cognition pyrethroid pesticide older adults NHANES Medicine R
Acceso en línea:	https://doaj.org/article/e500567abbc8466dad106b5ea17aed4d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e500567abbc8466dad106b5ea17aed4d
record_format	dspace
spelling	oai:doaj.org-article:e500567abbc8466dad106b5ea17aed4d2021-11-25T17:50:16ZEnvironmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001–200210.3390/ijerph1822120051660-46011661-7827https://doaj.org/article/e500567abbc8466dad106b5ea17aed4d2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/12005https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Pyrethroid compounds are widely used in household insecticides and agricultural pesticides. Recent studies, however, report that pyrethroid exposures affect neurobehavioral function in animals and may be associated with adverse neurocognitive development in children. This study aimed to examine the association between pyrethroid exposure and cognitive dysfunction in older adults using a well-defined general population. We analyzed data from 336 individuals, aged 60–84 years, who participated in the National Health and Nutrition Examination Survey 2001–2002. We used urinary 3-phenoxybenzoic acid (3-PBA) concentration as a biomarker of pyrethroid exposures and assessed cognitive function with the digit–symbol coding test. The geometric means (±geometric standard errors) of creatinine-uncorrected and corrected urinary 3-PBA were 0.30 (±0.87) μg/L and 0.36 (±0.89) μg/g. After adjusting for sociodemographic factors, higher 3-PBA concentrations (> vs. ≤0.30 μg/g creatinine (median)) were associated with lower scores of cognitive function (−3.83 95% confidence interval: −7.11, −0.54). Significance was persistent after additionally adjusting for physical activity and smoking pack-year (−3.76 95% CI: −7.16, −0.36) and further adjusting for BMI and presence of hypertension and diabetes (−3.82 95% CI: −6.92, −0.71). Our findings suggest that pyrethroid exposure is associated with cognitive dysfunction in older adults.Ui-Jin KimMyeongjin HongYoon-Hyeong ChoiMDPI AGarticlecognitionpyrethroidpesticideolder adultsNHANESMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 12005, p 12005 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognition pyrethroid pesticide older adults NHANES Medicine R
spellingShingle	cognition pyrethroid pesticide older adults NHANES Medicine R Ui-Jin Kim Myeongjin Hong Yoon-Hyeong Choi Environmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001–2002
description	Pyrethroid compounds are widely used in household insecticides and agricultural pesticides. Recent studies, however, report that pyrethroid exposures affect neurobehavioral function in animals and may be associated with adverse neurocognitive development in children. This study aimed to examine the association between pyrethroid exposure and cognitive dysfunction in older adults using a well-defined general population. We analyzed data from 336 individuals, aged 60–84 years, who participated in the National Health and Nutrition Examination Survey 2001–2002. We used urinary 3-phenoxybenzoic acid (3-PBA) concentration as a biomarker of pyrethroid exposures and assessed cognitive function with the digit–symbol coding test. The geometric means (±geometric standard errors) of creatinine-uncorrected and corrected urinary 3-PBA were 0.30 (±0.87) μg/L and 0.36 (±0.89) μg/g. After adjusting for sociodemographic factors, higher 3-PBA concentrations (> vs. ≤0.30 μg/g creatinine (median)) were associated with lower scores of cognitive function (−3.83 95% confidence interval: −7.11, −0.54). Significance was persistent after additionally adjusting for physical activity and smoking pack-year (−3.76 95% CI: −7.16, −0.36) and further adjusting for BMI and presence of hypertension and diabetes (−3.82 95% CI: −6.92, −0.71). Our findings suggest that pyrethroid exposure is associated with cognitive dysfunction in older adults.
format	article
author	Ui-Jin Kim Myeongjin Hong Yoon-Hyeong Choi
author_facet	Ui-Jin Kim Myeongjin Hong Yoon-Hyeong Choi
author_sort	Ui-Jin Kim
title	Environmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001–2002
title_short	Environmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001–2002
title_full	Environmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001–2002
title_fullStr	Environmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001–2002
title_full_unstemmed	Environmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001–2002
title_sort	environmental pyrethroid exposure and cognitive dysfunction in u.s. older adults: the nhanes 2001–2002
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e500567abbc8466dad106b5ea17aed4d
work_keys_str_mv	AT uijinkim environmentalpyrethroidexposureandcognitivedysfunctioninusolderadultsthenhanes20012002 AT myeongjinhong environmentalpyrethroidexposureandcognitivedysfunctioninusolderadultsthenhanes20012002 AT yoonhyeongchoi environmentalpyrethroidexposureandcognitivedysfunctioninusolderadultsthenhanes20012002
_version_	1718411955614515200

Environmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001–2002

Ejemplares similares