Broad-spectrum kinetic resolution of alcohols enabled by Cu–H-catalysed dehydrogenative coupling with hydrosilanes

Kinetic resolution of alcohols by silylation is an attractive method to produce enantiopure compounds, but known systems often display limited substrate scope. Here the authors report a copper catalysed enantioselective dehydrogenative silylation of alcohols that have high selectivity across a broad...

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Autores principales:	Xichang Dong, Andreas Weickgenannt, Martin Oestreich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e506d0b7d1b545dcbd08d7a705017f56
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spelling	oai:doaj.org-article:e506d0b7d1b545dcbd08d7a705017f562021-12-02T17:06:21ZBroad-spectrum kinetic resolution of alcohols enabled by Cu–H-catalysed dehydrogenative coupling with hydrosilanes10.1038/ncomms155472041-1723https://doaj.org/article/e506d0b7d1b545dcbd08d7a705017f562017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15547https://doaj.org/toc/2041-1723Kinetic resolution of alcohols by silylation is an attractive method to produce enantiopure compounds, but known systems often display limited substrate scope. Here the authors report a copper catalysed enantioselective dehydrogenative silylation of alcohols that have high selectivity across a broad range of substrates.Xichang DongAndreas WeickgenanntMartin OestreichNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xichang Dong Andreas Weickgenannt Martin Oestreich Broad-spectrum kinetic resolution of alcohols enabled by Cu–H-catalysed dehydrogenative coupling with hydrosilanes
description	Kinetic resolution of alcohols by silylation is an attractive method to produce enantiopure compounds, but known systems often display limited substrate scope. Here the authors report a copper catalysed enantioselective dehydrogenative silylation of alcohols that have high selectivity across a broad range of substrates.
format	article
author	Xichang Dong Andreas Weickgenannt Martin Oestreich
author_facet	Xichang Dong Andreas Weickgenannt Martin Oestreich
author_sort	Xichang Dong
title	Broad-spectrum kinetic resolution of alcohols enabled by Cu–H-catalysed dehydrogenative coupling with hydrosilanes
title_short	Broad-spectrum kinetic resolution of alcohols enabled by Cu–H-catalysed dehydrogenative coupling with hydrosilanes
title_full	Broad-spectrum kinetic resolution of alcohols enabled by Cu–H-catalysed dehydrogenative coupling with hydrosilanes
title_fullStr	Broad-spectrum kinetic resolution of alcohols enabled by Cu–H-catalysed dehydrogenative coupling with hydrosilanes
title_full_unstemmed	Broad-spectrum kinetic resolution of alcohols enabled by Cu–H-catalysed dehydrogenative coupling with hydrosilanes
title_sort	broad-spectrum kinetic resolution of alcohols enabled by cu–h-catalysed dehydrogenative coupling with hydrosilanes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e506d0b7d1b545dcbd08d7a705017f56
work_keys_str_mv	AT xichangdong broadspectrumkineticresolutionofalcoholsenabledbycuhcatalyseddehydrogenativecouplingwithhydrosilanes AT andreasweickgenannt broadspectrumkineticresolutionofalcoholsenabledbycuhcatalyseddehydrogenativecouplingwithhydrosilanes AT martinoestreich broadspectrumkineticresolutionofalcoholsenabledbycuhcatalyseddehydrogenativecouplingwithhydrosilanes
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Broad-spectrum kinetic resolution of alcohols enabled by Cu–H-catalysed dehydrogenative coupling with hydrosilanes

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