Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines

Abstract Breast cancer is the most prevalent malignancy amongst women worldwide while ovarian cancer represents the leading cause of death among gynecological malignancies. Women suffering from these cancers displayed heightened rates of major depressive disorder, and antidepressant treatment with s...

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Autores principales:	Britta Stapel, Catharina Melzer, Juliane von der Ohe, Peter Hillemanns, Stefan Bleich, Kai G. Kahl, Ralf Hass
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e507f04fc6874f6790b5573788c1ce10
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spelling	oai:doaj.org-article:e507f04fc6874f6790b5573788c1ce102021-12-02T15:23:04ZEffect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines10.1038/s41598-020-80850-92045-2322https://doaj.org/article/e507f04fc6874f6790b5573788c1ce102021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80850-9https://doaj.org/toc/2045-2322Abstract Breast cancer is the most prevalent malignancy amongst women worldwide while ovarian cancer represents the leading cause of death among gynecological malignancies. Women suffering from these cancers displayed heightened rates of major depressive disorder, and antidepressant treatment with selective serotonin reuptake inhibitors (SSRIs) is frequently recommended. Recently, narrative reviews and meta-analyses showed increased recurrence risks and mortality rates in SSRI-treated women with breast and ovarian cancer. We therefore examined whether three commonly prescribed SSRIs, fluoxetine, sertraline and citalopram, affect proliferation or glucose uptake of human breast and ovarian cancer cell lines characterized by different malignancies and metastatic potential. SSRI treatment or serotonin stimulation with therapeutically relevant concentrations over various time periods revealed no consistent dose- or time-dependent effect on proliferation rates. A marginal, but significant increase in glucose uptake was observed in SK-OV-3 ovarian cancer cells upon fluoxetine or sertraline, but not citalopram treatment. In three breast cancer cell lines and in two additional ovarian cancer cell lines no significant effect of SSRIs on glucose uptake was observed. Our data suggest that the observed increase in recurrence- and mortality rates in SSRI-treated cancer patients is unlikely to be linked to antidepressant therapies.Britta StapelCatharina MelzerJuliane von der OhePeter HillemannsStefan BleichKai G. KahlRalf HassNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Britta Stapel Catharina Melzer Juliane von der Ohe Peter Hillemanns Stefan Bleich Kai G. Kahl Ralf Hass Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines
description	Abstract Breast cancer is the most prevalent malignancy amongst women worldwide while ovarian cancer represents the leading cause of death among gynecological malignancies. Women suffering from these cancers displayed heightened rates of major depressive disorder, and antidepressant treatment with selective serotonin reuptake inhibitors (SSRIs) is frequently recommended. Recently, narrative reviews and meta-analyses showed increased recurrence risks and mortality rates in SSRI-treated women with breast and ovarian cancer. We therefore examined whether three commonly prescribed SSRIs, fluoxetine, sertraline and citalopram, affect proliferation or glucose uptake of human breast and ovarian cancer cell lines characterized by different malignancies and metastatic potential. SSRI treatment or serotonin stimulation with therapeutically relevant concentrations over various time periods revealed no consistent dose- or time-dependent effect on proliferation rates. A marginal, but significant increase in glucose uptake was observed in SK-OV-3 ovarian cancer cells upon fluoxetine or sertraline, but not citalopram treatment. In three breast cancer cell lines and in two additional ovarian cancer cell lines no significant effect of SSRIs on glucose uptake was observed. Our data suggest that the observed increase in recurrence- and mortality rates in SSRI-treated cancer patients is unlikely to be linked to antidepressant therapies.
format	article
author	Britta Stapel Catharina Melzer Juliane von der Ohe Peter Hillemanns Stefan Bleich Kai G. Kahl Ralf Hass
author_facet	Britta Stapel Catharina Melzer Juliane von der Ohe Peter Hillemanns Stefan Bleich Kai G. Kahl Ralf Hass
author_sort	Britta Stapel
title	Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines
title_short	Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines
title_full	Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines
title_fullStr	Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines
title_full_unstemmed	Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines
title_sort	effect of ssri exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e507f04fc6874f6790b5573788c1ce10
work_keys_str_mv	AT brittastapel effectofssriexposureontheproliferationrateandglucoseuptakeinbreastandovarycancercelllines AT catharinamelzer effectofssriexposureontheproliferationrateandglucoseuptakeinbreastandovarycancercelllines AT julianevonderohe effectofssriexposureontheproliferationrateandglucoseuptakeinbreastandovarycancercelllines AT peterhillemanns effectofssriexposureontheproliferationrateandglucoseuptakeinbreastandovarycancercelllines AT stefanbleich effectofssriexposureontheproliferationrateandglucoseuptakeinbreastandovarycancercelllines AT kaigkahl effectofssriexposureontheproliferationrateandglucoseuptakeinbreastandovarycancercelllines AT ralfhass effectofssriexposureontheproliferationrateandglucoseuptakeinbreastandovarycancercelllines
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Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines

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