FEATURES OF INTERRELATIONS BETWEEN IMMUNE STATUS INDICATORS AND AMOUNTS OF BLAST CELLS IN ACUTE LEUKEMIA

Аbstract. The purpose of study was to evaluate some characteristics of immune state in the patients with acute non-differentiated leukemia (ANLL) and acute lymphoblastic leukemia (ALL), and to detect interrelations between the features of immune state and their dependencies on disease stage and quan...

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Autores principales:	O. V. Smirnova, A. А. Savchenko, V. T. Manchouk
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	neuronet prediction blast cells acute leukemia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e5080d518c474bd18b57edf01a400440
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spelling	oai:doaj.org-article:e5080d518c474bd18b57edf01a4004402021-11-18T08:03:41ZFEATURES OF INTERRELATIONS BETWEEN IMMUNE STATUS INDICATORS AND AMOUNTS OF BLAST CELLS IN ACUTE LEUKEMIA1563-06252313-741X10.15789/1563-0625-2011-1-49-54https://doaj.org/article/e5080d518c474bd18b57edf01a4004402014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/415https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XАbstract. The purpose of study was to evaluate some characteristics of immune state in the patients with acute non-differentiated leukemia (ANLL) and acute lymphoblastic leukemia (ALL), and to detect interrelations between the features of immune state and their dependencies on disease stage and quantities of blast cells, using a neuronet modeling approach. A decrease in immune system reactivity was revealed in acute leukemia patients. At any ALL stage, a T-cell immunodeficiency is registered. A decrease of T lymphocyte amounts and reduction of CD4+:CD8+ ratio are associated with occurrence of ALL relapse. Increased contents of NK cells are a feature of ALL recurrence. T cell deficiency emerges during ANLL relapse and remission. Meanwhile, a combined immunodeficiency develops upon relapse of the disease, affecting both T and B systems of immune response. Exhaustion of NK cell contents is a characteristic feature of ANLL, thus potentially promoting progression and relapse of the disease. By means of a neuronet predictor, a significance of information for certain immune state parameters was assessed, by determining amounts of blast cells in bone marrow. It was found that a specific histogram of informativity is revealed for each group of the patients. A computer-based experiment was performed which proves the specificity of interrelations between the immune state indices in a neuroprediction model for ALL and ANLL. (Med. Immunol., 2011, vol. 13, N 1, pp 49-54)O. V. SmirnovaA. А. SavchenkoV. T. ManchoukSPb RAACIarticleneuronet predictionblast cellsacute leukemiaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 1, Pp 49-54 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	neuronet prediction blast cells acute leukemia Immunologic diseases. Allergy RC581-607
spellingShingle	neuronet prediction blast cells acute leukemia Immunologic diseases. Allergy RC581-607 O. V. Smirnova A. А. Savchenko V. T. Manchouk FEATURES OF INTERRELATIONS BETWEEN IMMUNE STATUS INDICATORS AND AMOUNTS OF BLAST CELLS IN ACUTE LEUKEMIA
description	Аbstract. The purpose of study was to evaluate some characteristics of immune state in the patients with acute non-differentiated leukemia (ANLL) and acute lymphoblastic leukemia (ALL), and to detect interrelations between the features of immune state and their dependencies on disease stage and quantities of blast cells, using a neuronet modeling approach. A decrease in immune system reactivity was revealed in acute leukemia patients. At any ALL stage, a T-cell immunodeficiency is registered. A decrease of T lymphocyte amounts and reduction of CD4+:CD8+ ratio are associated with occurrence of ALL relapse. Increased contents of NK cells are a feature of ALL recurrence. T cell deficiency emerges during ANLL relapse and remission. Meanwhile, a combined immunodeficiency develops upon relapse of the disease, affecting both T and B systems of immune response. Exhaustion of NK cell contents is a characteristic feature of ANLL, thus potentially promoting progression and relapse of the disease. By means of a neuronet predictor, a significance of information for certain immune state parameters was assessed, by determining amounts of blast cells in bone marrow. It was found that a specific histogram of informativity is revealed for each group of the patients. A computer-based experiment was performed which proves the specificity of interrelations between the immune state indices in a neuroprediction model for ALL and ANLL. (Med. Immunol., 2011, vol. 13, N 1, pp 49-54)
format	article
author	O. V. Smirnova A. А. Savchenko V. T. Manchouk
author_facet	O. V. Smirnova A. А. Savchenko V. T. Manchouk
author_sort	O. V. Smirnova
title	FEATURES OF INTERRELATIONS BETWEEN IMMUNE STATUS INDICATORS AND AMOUNTS OF BLAST CELLS IN ACUTE LEUKEMIA
title_short	FEATURES OF INTERRELATIONS BETWEEN IMMUNE STATUS INDICATORS AND AMOUNTS OF BLAST CELLS IN ACUTE LEUKEMIA
title_full	FEATURES OF INTERRELATIONS BETWEEN IMMUNE STATUS INDICATORS AND AMOUNTS OF BLAST CELLS IN ACUTE LEUKEMIA
title_fullStr	FEATURES OF INTERRELATIONS BETWEEN IMMUNE STATUS INDICATORS AND AMOUNTS OF BLAST CELLS IN ACUTE LEUKEMIA
title_full_unstemmed	FEATURES OF INTERRELATIONS BETWEEN IMMUNE STATUS INDICATORS AND AMOUNTS OF BLAST CELLS IN ACUTE LEUKEMIA
title_sort	features of interrelations between immune status indicators and amounts of blast cells in acute leukemia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/e5080d518c474bd18b57edf01a400440
work_keys_str_mv	AT ovsmirnova featuresofinterrelationsbetweenimmunestatusindicatorsandamountsofblastcellsinacuteleukemia AT aasavchenko featuresofinterrelationsbetweenimmunestatusindicatorsandamountsofblastcellsinacuteleukemia AT vtmanchouk featuresofinterrelationsbetweenimmunestatusindicatorsandamountsofblastcellsinacuteleukemia
_version_	1718422513589944320

FEATURES OF INTERRELATIONS BETWEEN IMMUNE STATUS INDICATORS AND AMOUNTS OF BLAST CELLS IN ACUTE LEUKEMIA

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