Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo

Background: Latanoprost [LT], a prostaglandin F2-alpha [PGF2α] analogue used in the treatment of glaucoma. It induces skin pigmentation in guinea pigs. The rationale of trying 5-fluorouracil [5‐FU] in vitiligo treatment may come from the first report of hyperpigmentation induced by 5‐FU as a side ef...

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Autores principales:	Rehab Abd El Razek, Zakaria Obaid, Osama Magdy Elshahat
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	latanoprost five-fluorouracil vitiligo dermabrasion Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e50837497d764862b16242ecc0ef052d
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spelling	oai:doaj.org-article:e50837497d764862b16242ecc0ef052d2021-12-02T16:35:05ZComparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo2636-41742682-378010.21608/ijma.2021.70410.1290https://doaj.org/article/e50837497d764862b16242ecc0ef052d2021-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_169689_c863dc71bb8424a99e672afaa154913e.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Latanoprost [LT], a prostaglandin F2-alpha [PGF2α] analogue used in the treatment of glaucoma. It induces skin pigmentation in guinea pigs. The rationale of trying 5-fluorouracil [5‐FU] in vitiligo treatment may come from the first report of hyperpigmentation induced by 5‐FU as a side effect in the skin tumors and psoriasis treatment The Aim of the work: Comparison between the efficacy of topical latanoprost versus topical 5-fluorouracil after skin dermabrasion in induction of skin repigmentation in stable non-segmental vitiligo. Patients and Methods: This study included thirty Egyptian patients, 18-60 years old, with stable non-segmental vitiligo. They were divided into: group [A] patients subjected to 5 fluorouracil after dermabrasion and group [B] patients subjected to latanoprost after dermabrasion then followed up every two weeks for three months. Result: There was no statistically significant difference between both groups regarding total response to treatment and degree of repigmentation. However, there was higher response to treatment in group A than group B. In both groups patients were satisfied with the degree of improvement. As regard complication there were minimal complications only one case of koebnerization and two cases of post inflammatory hyperpigmentation Conclusion: 5- fluorouracil 5% was associated with better improvement than latanoprost. However, the difference did not reach statistical significance. Patients reported high satisfaction with the two treatment modalities.Rehab Abd El RazekZakaria ObaidOsama Magdy ElshahatAl-Azhar University, Faculty of Medicine (Damietta)articlelatanoprostfive-fluorouracilvitiligodermabrasionMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 3, Pp 1550-1555 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	latanoprost five-fluorouracil vitiligo dermabrasion Medicine (General) R5-920
spellingShingle	latanoprost five-fluorouracil vitiligo dermabrasion Medicine (General) R5-920 Rehab Abd El Razek Zakaria Obaid Osama Magdy Elshahat Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo
description	Background: Latanoprost [LT], a prostaglandin F2-alpha [PGF2α] analogue used in the treatment of glaucoma. It induces skin pigmentation in guinea pigs. The rationale of trying 5-fluorouracil [5‐FU] in vitiligo treatment may come from the first report of hyperpigmentation induced by 5‐FU as a side effect in the skin tumors and psoriasis treatment The Aim of the work: Comparison between the efficacy of topical latanoprost versus topical 5-fluorouracil after skin dermabrasion in induction of skin repigmentation in stable non-segmental vitiligo. Patients and Methods: This study included thirty Egyptian patients, 18-60 years old, with stable non-segmental vitiligo. They were divided into: group [A] patients subjected to 5 fluorouracil after dermabrasion and group [B] patients subjected to latanoprost after dermabrasion then followed up every two weeks for three months. Result: There was no statistically significant difference between both groups regarding total response to treatment and degree of repigmentation. However, there was higher response to treatment in group A than group B. In both groups patients were satisfied with the degree of improvement. As regard complication there were minimal complications only one case of koebnerization and two cases of post inflammatory hyperpigmentation Conclusion: 5- fluorouracil 5% was associated with better improvement than latanoprost. However, the difference did not reach statistical significance. Patients reported high satisfaction with the two treatment modalities.
format	article
author	Rehab Abd El Razek Zakaria Obaid Osama Magdy Elshahat
author_facet	Rehab Abd El Razek Zakaria Obaid Osama Magdy Elshahat
author_sort	Rehab Abd El Razek
title	Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo
title_short	Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo
title_full	Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo
title_fullStr	Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo
title_full_unstemmed	Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo
title_sort	comparative study between topical latanoprost versus topical 5- fluorouracil after dermabrasion for treatment of non-segmental stable vitiligo
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/e50837497d764862b16242ecc0ef052d
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Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo

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