Localization and upregulation of survivin in cancer health disparities: a clinical perspective

Salma Khan,1,2 Heather Ferguson Bennit,1,2 Malyn May Asuncion Valenzuela,1,2 David Turay,1,3 Carlos J Diaz Osterman,1,2 Ron B Moyron,1,2 Grace E Esebanmen,1,2 Arjun Ashok,1,2 Nathan R Wall1,2 1Department of Biochemistry, 2Center for Health Disparities and Molecular Medicine, 3Department of Anatomy,...

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Autores principales:	Khan S, Ferguson Bennit H, Asuncion Valenzuela MM, Turay D, Diaz Osterman CJ, Moyron RB, Esebanmen GE, Ashok A, Wall NR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e50eb269141f4d299d10cae8a1a3ab41
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spelling	oai:doaj.org-article:e50eb269141f4d299d10cae8a1a3ab412021-12-02T05:49:16ZLocalization and upregulation of survivin in cancer health disparities: a clinical perspective1177-5491https://doaj.org/article/e50eb269141f4d299d10cae8a1a3ab412015-07-01T00:00:00Zhttp://www.dovepress.com/localization-and-upregulation-of-survivin-in-cancer-health-disparities-peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491Salma Khan,1,2 Heather Ferguson Bennit,1,2 Malyn May Asuncion Valenzuela,1,2 David Turay,1,3 Carlos J Diaz Osterman,1,2 Ron B Moyron,1,2 Grace E Esebanmen,1,2 Arjun Ashok,1,2 Nathan R Wall1,2 1Department of Biochemistry, 2Center for Health Disparities and Molecular Medicine, 3Department of Anatomy, Loma Linda University School of Medicine, Loma Linda, CA, USA Abstract: Survivin is one of the most important members of the inhibitors of apoptosis protein family, as it is expressed in most human cancers but is absent in normal, differentiated tissues. Lending to its importance, survivin has proven associations with apoptosis and cell cycle control, and has more recently been shown to modulate the tumor microenvironment and immune evasion as a result of its extracellular localization. Upregulation of survivin has been found in many cancers including breast, prostate, pancreatic, and hematological malignancies, and it may prove to be associated with the advanced presentation, poorer prognosis, and lower survival rates observed in ethnically diverse populations. Keywords: survivin, cancer, exosomes, health disparityKhan SFerguson Bennit HAsuncion Valenzuela MMTuray DDiaz Osterman CJMoyron RBEsebanmen GEAshok AWall NRDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2015, Iss default, Pp 57-67 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Khan S Ferguson Bennit H Asuncion Valenzuela MM Turay D Diaz Osterman CJ Moyron RB Esebanmen GE Ashok A Wall NR Localization and upregulation of survivin in cancer health disparities: a clinical perspective
description	Salma Khan,1,2 Heather Ferguson Bennit,1,2 Malyn May Asuncion Valenzuela,1,2 David Turay,1,3 Carlos J Diaz Osterman,1,2 Ron B Moyron,1,2 Grace E Esebanmen,1,2 Arjun Ashok,1,2 Nathan R Wall1,2 1Department of Biochemistry, 2Center for Health Disparities and Molecular Medicine, 3Department of Anatomy, Loma Linda University School of Medicine, Loma Linda, CA, USA Abstract: Survivin is one of the most important members of the inhibitors of apoptosis protein family, as it is expressed in most human cancers but is absent in normal, differentiated tissues. Lending to its importance, survivin has proven associations with apoptosis and cell cycle control, and has more recently been shown to modulate the tumor microenvironment and immune evasion as a result of its extracellular localization. Upregulation of survivin has been found in many cancers including breast, prostate, pancreatic, and hematological malignancies, and it may prove to be associated with the advanced presentation, poorer prognosis, and lower survival rates observed in ethnically diverse populations. Keywords: survivin, cancer, exosomes, health disparity
format	article
author	Khan S Ferguson Bennit H Asuncion Valenzuela MM Turay D Diaz Osterman CJ Moyron RB Esebanmen GE Ashok A Wall NR
author_facet	Khan S Ferguson Bennit H Asuncion Valenzuela MM Turay D Diaz Osterman CJ Moyron RB Esebanmen GE Ashok A Wall NR
author_sort	Khan S
title	Localization and upregulation of survivin in cancer health disparities: a clinical perspective
title_short	Localization and upregulation of survivin in cancer health disparities: a clinical perspective
title_full	Localization and upregulation of survivin in cancer health disparities: a clinical perspective
title_fullStr	Localization and upregulation of survivin in cancer health disparities: a clinical perspective
title_full_unstemmed	Localization and upregulation of survivin in cancer health disparities: a clinical perspective
title_sort	localization and upregulation of survivin in cancer health disparities: a clinical perspective
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/e50eb269141f4d299d10cae8a1a3ab41
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Localization and upregulation of survivin in cancer health disparities: a clinical perspective

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