Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering

The repair of critical bone defects remains challenging worldwide. Three canonical pillars (biomaterial scaffolds, bioactive molecules, and stem cells) of bone tissue engineering have been widely used for bone regeneration in separate or combined strategies, but the delivery of bioactive molecules h...

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Autores principales:	Zhuowen Hao, Zhenhua Xu, Xuan Wang, Yi Wang, Hanke Li, Tianhong Chen, Yingkun Hu, Renxin Chen, Kegang Huang, Chao Chen, Jingfeng Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	biophysical stimuli mesenchymal stem cells osteoinductive mechanisms biophysical transduction osteogenesis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e511cc2eeb134822b8b849422a8e169b
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spelling	oai:doaj.org-article:e511cc2eeb134822b8b849422a8e169b2021-11-09T06:23:10ZBiophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering2296-634X10.3389/fcell.2021.790050https://doaj.org/article/e511cc2eeb134822b8b849422a8e169b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.790050/fullhttps://doaj.org/toc/2296-634XThe repair of critical bone defects remains challenging worldwide. Three canonical pillars (biomaterial scaffolds, bioactive molecules, and stem cells) of bone tissue engineering have been widely used for bone regeneration in separate or combined strategies, but the delivery of bioactive molecules has several obvious drawbacks. Biophysical stimuli have great potential to become the fourth pillar of bone tissue engineering, which can be categorized into three groups depending on their physical properties: internal structural stimuli, external mechanical stimuli, and electromagnetic stimuli. In this review, distinctive biophysical stimuli coupled with their osteoinductive windows or parameters are initially presented to induce the osteogenesis of mesenchymal stem cells (MSCs). Then, osteoinductive mechanisms of biophysical transduction (a combination of mechanotransduction and electrocoupling) are reviewed to direct the osteogenic differentiation of MSCs. These mechanisms include biophysical sensing, transmission, and regulation. Furthermore, distinctive application strategies of biophysical stimuli are presented for bone tissue engineering, including predesigned biomaterials, tissue-engineered bone grafts, and postoperative biophysical stimuli loading strategies. Finally, ongoing challenges and future perspectives are discussed.Zhuowen HaoZhenhua XuXuan WangYi WangHanke LiTianhong ChenYingkun HuRenxin ChenKegang HuangChao ChenChao ChenJingfeng LiFrontiers Media S.A.articlebiophysical stimulimesenchymal stem cellsosteoinductive mechanismsbiophysical transductionosteogenesisBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biophysical stimuli mesenchymal stem cells osteoinductive mechanisms biophysical transduction osteogenesis Biology (General) QH301-705.5
spellingShingle	biophysical stimuli mesenchymal stem cells osteoinductive mechanisms biophysical transduction osteogenesis Biology (General) QH301-705.5 Zhuowen Hao Zhenhua Xu Xuan Wang Yi Wang Hanke Li Tianhong Chen Yingkun Hu Renxin Chen Kegang Huang Chao Chen Chao Chen Jingfeng Li Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering
description	The repair of critical bone defects remains challenging worldwide. Three canonical pillars (biomaterial scaffolds, bioactive molecules, and stem cells) of bone tissue engineering have been widely used for bone regeneration in separate or combined strategies, but the delivery of bioactive molecules has several obvious drawbacks. Biophysical stimuli have great potential to become the fourth pillar of bone tissue engineering, which can be categorized into three groups depending on their physical properties: internal structural stimuli, external mechanical stimuli, and electromagnetic stimuli. In this review, distinctive biophysical stimuli coupled with their osteoinductive windows or parameters are initially presented to induce the osteogenesis of mesenchymal stem cells (MSCs). Then, osteoinductive mechanisms of biophysical transduction (a combination of mechanotransduction and electrocoupling) are reviewed to direct the osteogenic differentiation of MSCs. These mechanisms include biophysical sensing, transmission, and regulation. Furthermore, distinctive application strategies of biophysical stimuli are presented for bone tissue engineering, including predesigned biomaterials, tissue-engineered bone grafts, and postoperative biophysical stimuli loading strategies. Finally, ongoing challenges and future perspectives are discussed.
format	article
author	Zhuowen Hao Zhenhua Xu Xuan Wang Yi Wang Hanke Li Tianhong Chen Yingkun Hu Renxin Chen Kegang Huang Chao Chen Chao Chen Jingfeng Li
author_facet	Zhuowen Hao Zhenhua Xu Xuan Wang Yi Wang Hanke Li Tianhong Chen Yingkun Hu Renxin Chen Kegang Huang Chao Chen Chao Chen Jingfeng Li
author_sort	Zhuowen Hao
title	Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering
title_short	Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering
title_full	Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering
title_fullStr	Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering
title_full_unstemmed	Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering
title_sort	biophysical stimuli as the fourth pillar of bone tissue engineering
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e511cc2eeb134822b8b849422a8e169b
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_version_	1718441343332646912

Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering

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