Magneto-nanosensor platform for probing low-affinity protein–protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction

Measurement of low-affinity protein–protein interactions is challenging; surface plasmon resonance requires high concentrations of reagents. Here the authors combine magneto-nanosensors with microfluidic chips and protein-conjugated magnetic nanoparticles to discover a low-affinity interaction betwe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jung-Rok Lee, Daniel J. B. Bechstein, Chin Chun Ooi, Ashka Patel, Richard S. Gaster, Elaine Ng, Lino C. Gonzalez, Shan X. Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e5190858f2fc4fbaa809b26cb3ad4f36
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e5190858f2fc4fbaa809b26cb3ad4f36
record_format	dspace
spelling	oai:doaj.org-article:e5190858f2fc4fbaa809b26cb3ad4f362021-12-02T16:49:43ZMagneto-nanosensor platform for probing low-affinity protein–protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction10.1038/ncomms122202041-1723https://doaj.org/article/e5190858f2fc4fbaa809b26cb3ad4f362016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12220https://doaj.org/toc/2041-1723Measurement of low-affinity protein–protein interactions is challenging; surface plasmon resonance requires high concentrations of reagents. Here the authors combine magneto-nanosensors with microfluidic chips and protein-conjugated magnetic nanoparticles to discover a low-affinity interaction between T-cell inhibitory receptors PD-L1 and PD-L2.Jung-Rok LeeDaniel J. B. BechsteinChin Chun OoiAshka PatelRichard S. GasterElaine NgLino C. GonzalezShan X. WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jung-Rok Lee Daniel J. B. Bechstein Chin Chun Ooi Ashka Patel Richard S. Gaster Elaine Ng Lino C. Gonzalez Shan X. Wang Magneto-nanosensor platform for probing low-affinity protein–protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction
description	Measurement of low-affinity protein–protein interactions is challenging; surface plasmon resonance requires high concentrations of reagents. Here the authors combine magneto-nanosensors with microfluidic chips and protein-conjugated magnetic nanoparticles to discover a low-affinity interaction between T-cell inhibitory receptors PD-L1 and PD-L2.
format	article
author	Jung-Rok Lee Daniel J. B. Bechstein Chin Chun Ooi Ashka Patel Richard S. Gaster Elaine Ng Lino C. Gonzalez Shan X. Wang
author_facet	Jung-Rok Lee Daniel J. B. Bechstein Chin Chun Ooi Ashka Patel Richard S. Gaster Elaine Ng Lino C. Gonzalez Shan X. Wang
author_sort	Jung-Rok Lee
title	Magneto-nanosensor platform for probing low-affinity protein–protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction
title_short	Magneto-nanosensor platform for probing low-affinity protein–protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction
title_full	Magneto-nanosensor platform for probing low-affinity protein–protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction
title_fullStr	Magneto-nanosensor platform for probing low-affinity protein–protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction
title_full_unstemmed	Magneto-nanosensor platform for probing low-affinity protein–protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction
title_sort	magneto-nanosensor platform for probing low-affinity protein–protein interactions and identification of a low-affinity pd-l1/pd-l2 interaction
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e5190858f2fc4fbaa809b26cb3ad4f36
work_keys_str_mv	AT jungroklee magnetonanosensorplatformforprobinglowaffinityproteinproteininteractionsandidentificationofalowaffinitypdl1pdl2interaction AT danieljbbechstein magnetonanosensorplatformforprobinglowaffinityproteinproteininteractionsandidentificationofalowaffinitypdl1pdl2interaction AT chinchunooi magnetonanosensorplatformforprobinglowaffinityproteinproteininteractionsandidentificationofalowaffinitypdl1pdl2interaction AT ashkapatel magnetonanosensorplatformforprobinglowaffinityproteinproteininteractionsandidentificationofalowaffinitypdl1pdl2interaction AT richardsgaster magnetonanosensorplatformforprobinglowaffinityproteinproteininteractionsandidentificationofalowaffinitypdl1pdl2interaction AT elaineng magnetonanosensorplatformforprobinglowaffinityproteinproteininteractionsandidentificationofalowaffinitypdl1pdl2interaction AT linocgonzalez magnetonanosensorplatformforprobinglowaffinityproteinproteininteractionsandidentificationofalowaffinitypdl1pdl2interaction AT shanxwang magnetonanosensorplatformforprobinglowaffinityproteinproteininteractionsandidentificationofalowaffinitypdl1pdl2interaction
_version_	1718383247633678336

Magneto-nanosensor platform for probing low-affinity protein–protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction

Ejemplares similares