Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer

The genomic features of metastatic prostate cancer are beginning to be understood. Here, the authors performed whole genome sequencing of plasma samples from these patients and found a high plasticity of the cancer genomes with newly occurring focal amplifications as a driving force in progression.

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Autores principales:	Peter Ulz, Jelena Belic, Ricarda Graf, Martina Auer, Ingrid Lafer, Katja Fischereder, Gerald Webersinke, Karl Pummer, Herbert Augustin, Martin Pichler, Gerald Hoefler, Thomas Bauernhofer, Jochen B. Geigl, Ellen Heitzer, Michael R. Speicher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e51914e35344497896933a5afa0a6ac1
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spelling	oai:doaj.org-article:e51914e35344497896933a5afa0a6ac12021-12-02T14:39:29ZWhole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer10.1038/ncomms120082041-1723https://doaj.org/article/e51914e35344497896933a5afa0a6ac12016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12008https://doaj.org/toc/2041-1723The genomic features of metastatic prostate cancer are beginning to be understood. Here, the authors performed whole genome sequencing of plasma samples from these patients and found a high plasticity of the cancer genomes with newly occurring focal amplifications as a driving force in progression.Peter UlzJelena BelicRicarda GrafMartina AuerIngrid LaferKatja FischerederGerald WebersinkeKarl PummerHerbert AugustinMartin PichlerGerald HoeflerThomas BauernhoferJochen B. GeiglEllen HeitzerMichael R. SpeicherNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter Ulz Jelena Belic Ricarda Graf Martina Auer Ingrid Lafer Katja Fischereder Gerald Webersinke Karl Pummer Herbert Augustin Martin Pichler Gerald Hoefler Thomas Bauernhofer Jochen B. Geigl Ellen Heitzer Michael R. Speicher Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer
description	The genomic features of metastatic prostate cancer are beginning to be understood. Here, the authors performed whole genome sequencing of plasma samples from these patients and found a high plasticity of the cancer genomes with newly occurring focal amplifications as a driving force in progression.
format	article
author	Peter Ulz Jelena Belic Ricarda Graf Martina Auer Ingrid Lafer Katja Fischereder Gerald Webersinke Karl Pummer Herbert Augustin Martin Pichler Gerald Hoefler Thomas Bauernhofer Jochen B. Geigl Ellen Heitzer Michael R. Speicher
author_facet	Peter Ulz Jelena Belic Ricarda Graf Martina Auer Ingrid Lafer Katja Fischereder Gerald Webersinke Karl Pummer Herbert Augustin Martin Pichler Gerald Hoefler Thomas Bauernhofer Jochen B. Geigl Ellen Heitzer Michael R. Speicher
author_sort	Peter Ulz
title	Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer
title_short	Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer
title_full	Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer
title_fullStr	Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer
title_full_unstemmed	Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer
title_sort	whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e51914e35344497896933a5afa0a6ac1
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Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer

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