Chitosan/Polyvinyl Alcohol/Tea Tree Essential Oil Composite Films for Biomedical Applications

Tissue engineering is crucial, since its early adoption focused on designing biocompatible materials that stimulate cell adhesion and proliferation. In this sense, scaffolds made of biocompatible and resistant materials became the researchers’ focus on biomedical applications. Humans have used essen...

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Autores principales:	Jorge Iván Castro, Carlos Humberto Valencia-Llano, Mayra Eliana Valencia Zapata, Yilmar Joan Restrepo, José Herminsul Mina Hernandez, Diana Paola Navia-Porras, Yamid Valencia, Cesar Valencia, Carlos David Grande-Tovar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biocompatibility chitosan tea tree essential oil membrane polyvinyl alcohol tissue engineering Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/e51984a72d0e41f3b2c7992595f1b8f2
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spelling	oai:doaj.org-article:e51984a72d0e41f3b2c7992595f1b8f22021-11-11T18:46:25ZChitosan/Polyvinyl Alcohol/Tea Tree Essential Oil Composite Films for Biomedical Applications10.3390/polym132137532073-4360https://doaj.org/article/e51984a72d0e41f3b2c7992595f1b8f22021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/21/3753https://doaj.org/toc/2073-4360Tissue engineering is crucial, since its early adoption focused on designing biocompatible materials that stimulate cell adhesion and proliferation. In this sense, scaffolds made of biocompatible and resistant materials became the researchers’ focus on biomedical applications. Humans have used essential oils for a long time to take advantage of their antifungal, insecticide, antibacterial, and antioxidant properties. However, the literature demonstrating the use of essential oils for stimulating biocompatibility in new scaffold designs is scarce. For that reason, this work describes the synthesis of four different film composites of chitosan/polyvinyl alcohol/tea tree (<i>Melaleuca alternifolia</i>), essential oil (CS/PVA/TTEO), and the subdermal implantations after 90 days in Wistar rats. According to the Young modulus, DSC, TGA, mechanical studies, and thermal studies, there was a reinforcement effect with the addition of TTEO. Morphology and energy-dispersive (EDX) analysis after the immersion in simulated body fluid (SBF) exhibited a light layer of calcium chloride and sodium chloride generated on the material’s surface, which is generally related to a bioactive material. Finally, the biocompatibility of the films was comparable with porcine collagen, showing better signs of resorption as the amount of TTEO was increased. These results indicate the potential application of the films in long-term biomedical needs.Jorge Iván CastroCarlos Humberto Valencia-LlanoMayra Eliana Valencia ZapataYilmar Joan RestrepoJosé Herminsul Mina HernandezDiana Paola Navia-PorrasYamid ValenciaCesar ValenciaCarlos David Grande-TovarMDPI AGarticlebiocompatibilitychitosantea tree essential oilmembranepolyvinyl alcoholtissue engineeringOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3753, p 3753 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biocompatibility chitosan tea tree essential oil membrane polyvinyl alcohol tissue engineering Organic chemistry QD241-441
spellingShingle	biocompatibility chitosan tea tree essential oil membrane polyvinyl alcohol tissue engineering Organic chemistry QD241-441 Jorge Iván Castro Carlos Humberto Valencia-Llano Mayra Eliana Valencia Zapata Yilmar Joan Restrepo José Herminsul Mina Hernandez Diana Paola Navia-Porras Yamid Valencia Cesar Valencia Carlos David Grande-Tovar Chitosan/Polyvinyl Alcohol/Tea Tree Essential Oil Composite Films for Biomedical Applications
description	Tissue engineering is crucial, since its early adoption focused on designing biocompatible materials that stimulate cell adhesion and proliferation. In this sense, scaffolds made of biocompatible and resistant materials became the researchers’ focus on biomedical applications. Humans have used essential oils for a long time to take advantage of their antifungal, insecticide, antibacterial, and antioxidant properties. However, the literature demonstrating the use of essential oils for stimulating biocompatibility in new scaffold designs is scarce. For that reason, this work describes the synthesis of four different film composites of chitosan/polyvinyl alcohol/tea tree (<i>Melaleuca alternifolia</i>), essential oil (CS/PVA/TTEO), and the subdermal implantations after 90 days in Wistar rats. According to the Young modulus, DSC, TGA, mechanical studies, and thermal studies, there was a reinforcement effect with the addition of TTEO. Morphology and energy-dispersive (EDX) analysis after the immersion in simulated body fluid (SBF) exhibited a light layer of calcium chloride and sodium chloride generated on the material’s surface, which is generally related to a bioactive material. Finally, the biocompatibility of the films was comparable with porcine collagen, showing better signs of resorption as the amount of TTEO was increased. These results indicate the potential application of the films in long-term biomedical needs.
format	article
author	Jorge Iván Castro Carlos Humberto Valencia-Llano Mayra Eliana Valencia Zapata Yilmar Joan Restrepo José Herminsul Mina Hernandez Diana Paola Navia-Porras Yamid Valencia Cesar Valencia Carlos David Grande-Tovar
author_facet	Jorge Iván Castro Carlos Humberto Valencia-Llano Mayra Eliana Valencia Zapata Yilmar Joan Restrepo José Herminsul Mina Hernandez Diana Paola Navia-Porras Yamid Valencia Cesar Valencia Carlos David Grande-Tovar
author_sort	Jorge Iván Castro
title	Chitosan/Polyvinyl Alcohol/Tea Tree Essential Oil Composite Films for Biomedical Applications
title_short	Chitosan/Polyvinyl Alcohol/Tea Tree Essential Oil Composite Films for Biomedical Applications
title_full	Chitosan/Polyvinyl Alcohol/Tea Tree Essential Oil Composite Films for Biomedical Applications
title_fullStr	Chitosan/Polyvinyl Alcohol/Tea Tree Essential Oil Composite Films for Biomedical Applications
title_full_unstemmed	Chitosan/Polyvinyl Alcohol/Tea Tree Essential Oil Composite Films for Biomedical Applications
title_sort	chitosan/polyvinyl alcohol/tea tree essential oil composite films for biomedical applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e51984a72d0e41f3b2c7992595f1b8f2
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Chitosan/Polyvinyl Alcohol/Tea Tree Essential Oil Composite Films for Biomedical Applications

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