Herpesviral ICP0 Protein Promotes Two Waves of Heterochromatin Removal on an Early Viral Promoter during Lytic Infection

ABSTRACT Herpesviruses must contend with host cell epigenetic silencing responses acting on their genomes upon entry into the host cell nucleus. In this study, we confirmed that unchromatinized herpes simplex virus 1 (HSV-1) genomes enter primary human foreskin fibroblasts and are rapidly subjected...

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Bibliographic Details
Main Authors: Jennifer S. Lee, Priya Raja, David M. Knipe
Format: article
Language:EN
Published: American Society for Microbiology 2016
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Online Access:https://doaj.org/article/e51a45f5c47745af80dae800a90d6dfb
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