Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome

Abstract Polycystic ovary syndrome (PCOS) women have a hypercoagulable state; however, whether this is intrinsically due to PCOS or, alternatively, a consequence of its metabolic complications is unclear. We determined plasma coagulation pathway protein levels in PCOS (n = 146) and control (n = 97)...

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Autores principales:	Abu Saleh Md Moin, Thozhukat Sathyapalan, Ilhame Diboun, Mohamed A. Elrayess, Alexandra E. Butler, Stephen L. Atkin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e51be4a72d3e48818948f31b3f80c4ae
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spelling	oai:doaj.org-article:e51be4a72d3e48818948f31b3f80c4ae2021-12-02T13:34:46ZMetabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome10.1038/s41598-021-84586-y2045-2322https://doaj.org/article/e51be4a72d3e48818948f31b3f80c4ae2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84586-yhttps://doaj.org/toc/2045-2322Abstract Polycystic ovary syndrome (PCOS) women have a hypercoagulable state; however, whether this is intrinsically due to PCOS or, alternatively, a consequence of its metabolic complications is unclear. We determined plasma coagulation pathway protein levels in PCOS (n = 146) and control (n = 97) women recruited to a PCOS biobank. Circulating levels of a panel of 18 clotting pathway proteins were determined by Slow Off-rate Modified Aptamer-scan plasma protein measurement. Cohorts were age matched, though PCOS had elevated body mass index (p < 0.001), insulin (p < 0.001) and C-reactive protein (CRP) (p < 0.0001). Eight pro-coagulation proteins were elevated in PCOS: plasminogen activator inhibitor-1 (p < 0.0001), fibrinogen (p < 0.01), fibrinogen gamma chain (p < 0.0001), fibronectin (p < 0.01), von Willebrand factor (p < 0.05), D-dimer (p < 0.0001), P-selectin (p < 0.05), and plasma kallikrein (p < 0.001). However, two anticoagulant proteins, vitamin K-dependent protein-S (p < 0.0001) and heparin cofactor-II (p < 0.001) were elevated and prothrombin was decreased (p < 0.05). CRP, as a marker of inflammation, and insulin resistance (HOMA-IR) correlated with 11 and 6 of the clotting proteins, respectively (p < 0.05). When matched for BMI < 25 (16 PCOS, 53 controls) HOMA-IR remained elevated (p < 0.05) and heparin cofactor-II was increased (p < 0.05). In a multivariate analysis accounting for inflammation, insulin resistance and BMI, there was no correlation of PCOS with any of the coagulation proteins. The hypercoagulable state in PCOS is not intrinsic to the disease as it can be fully accounted for by BMI, inflammation and insulin resistance.Abu Saleh Md MoinThozhukat SathyapalanIlhame DibounMohamed A. ElrayessAlexandra E. ButlerStephen L. AtkinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Abu Saleh Md Moin Thozhukat Sathyapalan Ilhame Diboun Mohamed A. Elrayess Alexandra E. Butler Stephen L. Atkin Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome
description	Abstract Polycystic ovary syndrome (PCOS) women have a hypercoagulable state; however, whether this is intrinsically due to PCOS or, alternatively, a consequence of its metabolic complications is unclear. We determined plasma coagulation pathway protein levels in PCOS (n = 146) and control (n = 97) women recruited to a PCOS biobank. Circulating levels of a panel of 18 clotting pathway proteins were determined by Slow Off-rate Modified Aptamer-scan plasma protein measurement. Cohorts were age matched, though PCOS had elevated body mass index (p < 0.001), insulin (p < 0.001) and C-reactive protein (CRP) (p < 0.0001). Eight pro-coagulation proteins were elevated in PCOS: plasminogen activator inhibitor-1 (p < 0.0001), fibrinogen (p < 0.01), fibrinogen gamma chain (p < 0.0001), fibronectin (p < 0.01), von Willebrand factor (p < 0.05), D-dimer (p < 0.0001), P-selectin (p < 0.05), and plasma kallikrein (p < 0.001). However, two anticoagulant proteins, vitamin K-dependent protein-S (p < 0.0001) and heparin cofactor-II (p < 0.001) were elevated and prothrombin was decreased (p < 0.05). CRP, as a marker of inflammation, and insulin resistance (HOMA-IR) correlated with 11 and 6 of the clotting proteins, respectively (p < 0.05). When matched for BMI < 25 (16 PCOS, 53 controls) HOMA-IR remained elevated (p < 0.05) and heparin cofactor-II was increased (p < 0.05). In a multivariate analysis accounting for inflammation, insulin resistance and BMI, there was no correlation of PCOS with any of the coagulation proteins. The hypercoagulable state in PCOS is not intrinsic to the disease as it can be fully accounted for by BMI, inflammation and insulin resistance.
format	article
author	Abu Saleh Md Moin Thozhukat Sathyapalan Ilhame Diboun Mohamed A. Elrayess Alexandra E. Butler Stephen L. Atkin
author_facet	Abu Saleh Md Moin Thozhukat Sathyapalan Ilhame Diboun Mohamed A. Elrayess Alexandra E. Butler Stephen L. Atkin
author_sort	Abu Saleh Md Moin
title	Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome
title_short	Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome
title_full	Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome
title_fullStr	Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome
title_full_unstemmed	Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome
title_sort	metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e51be4a72d3e48818948f31b3f80c4ae
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Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome

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