Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases

The Cia21 locus on chromosome 3 has been associated with rheumatoid arthritis severity in females. Here the authors show this locus houses a non-coding polymorphic estrogen receptor binding site and how it regulates neighbouring gene expression of CD2, implicating CD2 signalling in the sexual dimorp...

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Autores principales:	Gonzalo Fernandez Lahore, Michael Förster, Martina Johannesson, Pierre Sabatier, Erik Lönnblom, Mike Aoun, Yibo He, Kutty Selva Nandakumar, Roman A. Zubarev, Rikard Holmdahl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e51fe7ce4257487fbcf6b9aedb078673
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spelling	oai:doaj.org-article:e51fe7ce4257487fbcf6b9aedb0786732021-12-02T18:48:11ZPolymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases10.1038/s41467-021-25828-52041-1723https://doaj.org/article/e51fe7ce4257487fbcf6b9aedb0786732021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25828-5https://doaj.org/toc/2041-1723The Cia21 locus on chromosome 3 has been associated with rheumatoid arthritis severity in females. Here the authors show this locus houses a non-coding polymorphic estrogen receptor binding site and how it regulates neighbouring gene expression of CD2, implicating CD2 signalling in the sexual dimorphism of a variety of T cell-dependent autoimmune diseases.Gonzalo Fernandez LahoreMichael FörsterMartina JohannessonPierre SabatierErik LönnblomMike AounYibo HeKutty Selva NandakumarRoman A. ZubarevRikard HolmdahlNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gonzalo Fernandez Lahore Michael Förster Martina Johannesson Pierre Sabatier Erik Lönnblom Mike Aoun Yibo He Kutty Selva Nandakumar Roman A. Zubarev Rikard Holmdahl Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases
description	The Cia21 locus on chromosome 3 has been associated with rheumatoid arthritis severity in females. Here the authors show this locus houses a non-coding polymorphic estrogen receptor binding site and how it regulates neighbouring gene expression of CD2, implicating CD2 signalling in the sexual dimorphism of a variety of T cell-dependent autoimmune diseases.
format	article
author	Gonzalo Fernandez Lahore Michael Förster Martina Johannesson Pierre Sabatier Erik Lönnblom Mike Aoun Yibo He Kutty Selva Nandakumar Roman A. Zubarev Rikard Holmdahl
author_facet	Gonzalo Fernandez Lahore Michael Förster Martina Johannesson Pierre Sabatier Erik Lönnblom Mike Aoun Yibo He Kutty Selva Nandakumar Roman A. Zubarev Rikard Holmdahl
author_sort	Gonzalo Fernandez Lahore
title	Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases
title_short	Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases
title_full	Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases
title_fullStr	Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases
title_full_unstemmed	Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases
title_sort	polymorphic estrogen receptor binding site causes cd2-dependent sex bias in the susceptibility to autoimmune diseases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e51fe7ce4257487fbcf6b9aedb078673
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Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases

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