The Sec63p J-domain is required for ERAD of soluble proteins in yeast.

How misfolded proteins are exported from the ER to the cytosol for degradation (ER-associated Degradation, ERAD) and which proteins are participating in this process is not understood. Several studies using a single, leaky mutant indicated that Sec63p might be involved in ERAD. More recently, Sec63p...

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Autores principales: Christina Servas, Karin Römisch
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/e5241ed9947846919e346a6d1ddb9377
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