Difference in the plasma level of miR‐628‐3p in atopic dermatitis patients with/without atopic keratoconjunctivitis

Abstract Introduction Some but not all patients with atopic dermatitis (AD) present with allergic conjunctival disease (ACD) including severe types such as atopic keratoconjunctivitis (AKC) with/without giant papillae. We hypothesized that different factors are involved in the severity of ACD and AD...

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Autores principales:	Mayumi Ueta, Hiromi Nishigaki, Seitaro Komai, Chie Sotozono, Shigeru Kinoshita
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	allergy processes epigenetics processes human mucosa tissues Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e52763867f10454698cf3ce38c100299
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spelling	oai:doaj.org-article:e52763867f10454698cf3ce38c1002992021-11-12T19:57:15ZDifference in the plasma level of miR‐628‐3p in atopic dermatitis patients with/without atopic keratoconjunctivitis2050-452710.1002/iid3.536https://doaj.org/article/e52763867f10454698cf3ce38c1002992021-12-01T00:00:00Zhttps://doi.org/10.1002/iid3.536https://doaj.org/toc/2050-4527Abstract Introduction Some but not all patients with atopic dermatitis (AD) present with allergic conjunctival disease (ACD) including severe types such as atopic keratoconjunctivitis (AKC) with/without giant papillae. We hypothesized that different factors are involved in the severity of ACD and AD. Recently we reported that hsa‐miR‐628‐3p could affect the balance of innate immunity by suppressing pathogen‐associated molecular patterns such as toll‐like receptor 3 (TLR3), RIG‐I, and MDA‐5. We also reported that TLR3 positively regulates ocular surface‐ and skin inflammation such as contact dermatitis and AD. Here we compared the plasma level of miR‐628‐3p in AD patients with severe AKC with giant papillae and/or shield ulcers, with the level in healthy controls and AD patient without AKC or with very mild AKC. Methods We used the plasma from 32 AD patients with severe AKC, from 40 healthy controls, and from 23 AD patient without AKC or with very mild AKC without giant papillae nor shield ulcers. Quantitative microRNA PCR assays were used to measure their plasma level of miR‐628‐3p. Results We found that plasma miR‐628‐3p was upregulated in AD with severe AKC, but not in severe AD without severe AKC, nor in our healthy controls. Conclusion Our new findings suggest that the plasma miR‐628‐3p level may represent a marker to predict the presence of severe AKC in AD patients.Mayumi UetaHiromi NishigakiSeitaro KomaiChie SotozonoShigeru KinoshitaWileyarticleallergy processesepigenetics processeshumanmucosa tissuesImmunologic diseases. AllergyRC581-607ENImmunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1815-1819 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	allergy processes epigenetics processes human mucosa tissues Immunologic diseases. Allergy RC581-607
spellingShingle	allergy processes epigenetics processes human mucosa tissues Immunologic diseases. Allergy RC581-607 Mayumi Ueta Hiromi Nishigaki Seitaro Komai Chie Sotozono Shigeru Kinoshita Difference in the plasma level of miR‐628‐3p in atopic dermatitis patients with/without atopic keratoconjunctivitis
description	Abstract Introduction Some but not all patients with atopic dermatitis (AD) present with allergic conjunctival disease (ACD) including severe types such as atopic keratoconjunctivitis (AKC) with/without giant papillae. We hypothesized that different factors are involved in the severity of ACD and AD. Recently we reported that hsa‐miR‐628‐3p could affect the balance of innate immunity by suppressing pathogen‐associated molecular patterns such as toll‐like receptor 3 (TLR3), RIG‐I, and MDA‐5. We also reported that TLR3 positively regulates ocular surface‐ and skin inflammation such as contact dermatitis and AD. Here we compared the plasma level of miR‐628‐3p in AD patients with severe AKC with giant papillae and/or shield ulcers, with the level in healthy controls and AD patient without AKC or with very mild AKC. Methods We used the plasma from 32 AD patients with severe AKC, from 40 healthy controls, and from 23 AD patient without AKC or with very mild AKC without giant papillae nor shield ulcers. Quantitative microRNA PCR assays were used to measure their plasma level of miR‐628‐3p. Results We found that plasma miR‐628‐3p was upregulated in AD with severe AKC, but not in severe AD without severe AKC, nor in our healthy controls. Conclusion Our new findings suggest that the plasma miR‐628‐3p level may represent a marker to predict the presence of severe AKC in AD patients.
format	article
author	Mayumi Ueta Hiromi Nishigaki Seitaro Komai Chie Sotozono Shigeru Kinoshita
author_facet	Mayumi Ueta Hiromi Nishigaki Seitaro Komai Chie Sotozono Shigeru Kinoshita
author_sort	Mayumi Ueta
title	Difference in the plasma level of miR‐628‐3p in atopic dermatitis patients with/without atopic keratoconjunctivitis
title_short	Difference in the plasma level of miR‐628‐3p in atopic dermatitis patients with/without atopic keratoconjunctivitis
title_full	Difference in the plasma level of miR‐628‐3p in atopic dermatitis patients with/without atopic keratoconjunctivitis
title_fullStr	Difference in the plasma level of miR‐628‐3p in atopic dermatitis patients with/without atopic keratoconjunctivitis
title_full_unstemmed	Difference in the plasma level of miR‐628‐3p in atopic dermatitis patients with/without atopic keratoconjunctivitis
title_sort	difference in the plasma level of mir‐628‐3p in atopic dermatitis patients with/without atopic keratoconjunctivitis
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/e52763867f10454698cf3ce38c100299
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Difference in the plasma level of miR‐628‐3p in atopic dermatitis patients with/without atopic keratoconjunctivitis

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