PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2

Cardiomyocyte maturation and the acquisition of phenotypes is poorly understood at the single cell level. Here, the authors analyse the transcriptome of single cells from neonatal to adult heart and reveal that peroxisome proliferator-activated receptor coactivator-1 mediates the phenotypic shift.

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Autores principales:	Sean A. Murphy, Matthew Miyamoto, Anaïs Kervadec, Suraj Kannan, Emmanouil Tampakakis, Sandeep Kambhampati, Brian Leei Lin, Sam Paek, Peter Andersen, Dong-Ik Lee, Renjun Zhu, Steven S. An, David A. Kass, Hideki Uosaki, Alexandre R. Colas, Chulan Kwon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e529861439104233888f042c1cc8bff3
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spelling	oai:doaj.org-article:e529861439104233888f042c1cc8bff32021-12-02T11:36:20ZPGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B210.1038/s41467-021-21957-z2041-1723https://doaj.org/article/e529861439104233888f042c1cc8bff32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21957-zhttps://doaj.org/toc/2041-1723Cardiomyocyte maturation and the acquisition of phenotypes is poorly understood at the single cell level. Here, the authors analyse the transcriptome of single cells from neonatal to adult heart and reveal that peroxisome proliferator-activated receptor coactivator-1 mediates the phenotypic shift.Sean A. MurphyMatthew MiyamotoAnaïs KervadecSuraj KannanEmmanouil TampakakisSandeep KambhampatiBrian Leei LinSam PaekPeter AndersenDong-Ik LeeRenjun ZhuSteven S. AnDavid A. KassHideki UosakiAlexandre R. ColasChulan KwonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sean A. Murphy Matthew Miyamoto Anaïs Kervadec Suraj Kannan Emmanouil Tampakakis Sandeep Kambhampati Brian Leei Lin Sam Paek Peter Andersen Dong-Ik Lee Renjun Zhu Steven S. An David A. Kass Hideki Uosaki Alexandre R. Colas Chulan Kwon PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2
description	Cardiomyocyte maturation and the acquisition of phenotypes is poorly understood at the single cell level. Here, the authors analyse the transcriptome of single cells from neonatal to adult heart and reveal that peroxisome proliferator-activated receptor coactivator-1 mediates the phenotypic shift.
format	article
author	Sean A. Murphy Matthew Miyamoto Anaïs Kervadec Suraj Kannan Emmanouil Tampakakis Sandeep Kambhampati Brian Leei Lin Sam Paek Peter Andersen Dong-Ik Lee Renjun Zhu Steven S. An David A. Kass Hideki Uosaki Alexandre R. Colas Chulan Kwon
author_facet	Sean A. Murphy Matthew Miyamoto Anaïs Kervadec Suraj Kannan Emmanouil Tampakakis Sandeep Kambhampati Brian Leei Lin Sam Paek Peter Andersen Dong-Ik Lee Renjun Zhu Steven S. An David A. Kass Hideki Uosaki Alexandre R. Colas Chulan Kwon
author_sort	Sean A. Murphy
title	PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2
title_short	PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2
title_full	PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2
title_fullStr	PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2
title_full_unstemmed	PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2
title_sort	pgc1/ppar drive cardiomyocyte maturation at single cell level via yap1 and sf3b2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e529861439104233888f042c1cc8bff3
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PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2

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