Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors

miRNAs have emerged as regulators of diverse biological processes including cancer. Here the authors present an extended pan-cancer analysis of the miRNAs in 15 epithelial cancers; integrating methylation, transcriptomic and mutation data they reveal alternative mechanisms of tumour suppressors’ reg...

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Autores principales:	Andrew Dhawan, Jacob G. Scott, Adrian L. Harris, Francesca M. Buffa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e52ce54346f6441bb9b0292d33a78d34
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spelling	oai:doaj.org-article:e52ce54346f6441bb9b0292d33a78d342021-12-02T15:34:24ZPan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors10.1038/s41467-018-07657-12041-1723https://doaj.org/article/e52ce54346f6441bb9b0292d33a78d342018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07657-1https://doaj.org/toc/2041-1723miRNAs have emerged as regulators of diverse biological processes including cancer. Here the authors present an extended pan-cancer analysis of the miRNAs in 15 epithelial cancers; integrating methylation, transcriptomic and mutation data they reveal alternative mechanisms of tumour suppressors’ regulation in absence of mutation, methylation or copy number alterations.Andrew DhawanJacob G. ScottAdrian L. HarrisFrancesca M. BuffaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew Dhawan Jacob G. Scott Adrian L. Harris Francesca M. Buffa Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors
description	miRNAs have emerged as regulators of diverse biological processes including cancer. Here the authors present an extended pan-cancer analysis of the miRNAs in 15 epithelial cancers; integrating methylation, transcriptomic and mutation data they reveal alternative mechanisms of tumour suppressors’ regulation in absence of mutation, methylation or copy number alterations.
format	article
author	Andrew Dhawan Jacob G. Scott Adrian L. Harris Francesca M. Buffa
author_facet	Andrew Dhawan Jacob G. Scott Adrian L. Harris Francesca M. Buffa
author_sort	Andrew Dhawan
title	Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors
title_short	Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors
title_full	Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors
title_fullStr	Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors
title_full_unstemmed	Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors
title_sort	pan-cancer characterisation of microrna across cancer hallmarks reveals microrna-mediated downregulation of tumour suppressors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e52ce54346f6441bb9b0292d33a78d34
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Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors

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