Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema

Dysfunction of the lymphatic system leads to secondary lymphedema and results in degradation of quality of life. Here, the authors show that delivery of nucleoside-modified Vascular Endothelial Growth Factor C (VEGFC) mRNA, encapsulated in lipid nanoparticles, induces organ-specific lymphatic growth...

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Autores principales:	Dániel Szőke, Gábor Kovács, Éva Kemecsei, László Bálint, Kitti Szoták-Ajtay, Petra Aradi, Andrea Styevkóné Dinnyés, Barbara L. Mui, Ying K. Tam, Thomas D. Madden, Katalin Karikó, Raghu P. Kataru, Michael J. Hope, Drew Weissman, Babak J. Mehrara, Norbert Pardi, Zoltán Jakus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e53077cda0b04c41bea9adf1cf679075
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spelling	oai:doaj.org-article:e53077cda0b04c41bea9adf1cf6790752021-12-02T18:06:25ZNucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema10.1038/s41467-021-23546-62041-1723https://doaj.org/article/e53077cda0b04c41bea9adf1cf6790752021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23546-6https://doaj.org/toc/2041-1723Dysfunction of the lymphatic system leads to secondary lymphedema and results in degradation of quality of life. Here, the authors show that delivery of nucleoside-modified Vascular Endothelial Growth Factor C (VEGFC) mRNA, encapsulated in lipid nanoparticles, induces organ-specific lymphatic growth and reverses experimental lymphedema.Dániel SzőkeGábor KovácsÉva KemecseiLászló BálintKitti Szoták-AjtayPetra AradiAndrea Styevkóné DinnyésBarbara L. MuiYing K. TamThomas D. MaddenKatalin KarikóRaghu P. KataruMichael J. HopeDrew WeissmanBabak J. MehraraNorbert PardiZoltán JakusNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dániel Szőke Gábor Kovács Éva Kemecsei László Bálint Kitti Szoták-Ajtay Petra Aradi Andrea Styevkóné Dinnyés Barbara L. Mui Ying K. Tam Thomas D. Madden Katalin Karikó Raghu P. Kataru Michael J. Hope Drew Weissman Babak J. Mehrara Norbert Pardi Zoltán Jakus Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema
description	Dysfunction of the lymphatic system leads to secondary lymphedema and results in degradation of quality of life. Here, the authors show that delivery of nucleoside-modified Vascular Endothelial Growth Factor C (VEGFC) mRNA, encapsulated in lipid nanoparticles, induces organ-specific lymphatic growth and reverses experimental lymphedema.
format	article
author	Dániel Szőke Gábor Kovács Éva Kemecsei László Bálint Kitti Szoták-Ajtay Petra Aradi Andrea Styevkóné Dinnyés Barbara L. Mui Ying K. Tam Thomas D. Madden Katalin Karikó Raghu P. Kataru Michael J. Hope Drew Weissman Babak J. Mehrara Norbert Pardi Zoltán Jakus
author_facet	Dániel Szőke Gábor Kovács Éva Kemecsei László Bálint Kitti Szoták-Ajtay Petra Aradi Andrea Styevkóné Dinnyés Barbara L. Mui Ying K. Tam Thomas D. Madden Katalin Karikó Raghu P. Kataru Michael J. Hope Drew Weissman Babak J. Mehrara Norbert Pardi Zoltán Jakus
author_sort	Dániel Szőke
title	Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema
title_short	Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema
title_full	Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema
title_fullStr	Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema
title_full_unstemmed	Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema
title_sort	nucleoside-modified vegfc mrna induces organ-specific lymphatic growth and reverses experimental lymphedema
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e53077cda0b04c41bea9adf1cf679075
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Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema

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