Rapid temporal control of Foxp3 protein degradation by sirtuin-1.

Rapid temporal control of Foxp3 protein degradation by sirtuin-1.

Maintenance of Foxp3 protein expression in regulatory T cells (Treg) is crucial for a balanced immune response. We have previously demonstrated that Foxp3 protein stability can be regulated through acetylation, however the specific mechanisms underlying this observation remain unclear. Here we demon...

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Autores principales: Jorg van Loosdregt, Diede Brunen, Veerle Fleskens, Cornelieke E G M Pals, Eric W F Lam, Paul J Coffer
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e5310b45f1a746f49c5370dcb0f464d9
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