Molecular pathogenesis of rhegmatogenous retinal detachment

Abstract Rhegmatogenous retinal detachment (RRD) is an ophthalmic emergency, which usually requires prompt surgery to prevent further detachment and restore sensory function. Although several individual factors have been suggested, a systems level understanding of molecular pathomechanisms underlyin...

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Autores principales:	Tiina Öhman, Lisa Gawriyski, Sini Miettinen, Markku Varjosalo, Sirpa Loukovaara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e531e06d2a9a4032bafd6a24e1e61c57
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spelling	oai:doaj.org-article:e531e06d2a9a4032bafd6a24e1e61c572021-12-02T14:01:37ZMolecular pathogenesis of rhegmatogenous retinal detachment10.1038/s41598-020-80005-w2045-2322https://doaj.org/article/e531e06d2a9a4032bafd6a24e1e61c572021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80005-whttps://doaj.org/toc/2045-2322Abstract Rhegmatogenous retinal detachment (RRD) is an ophthalmic emergency, which usually requires prompt surgery to prevent further detachment and restore sensory function. Although several individual factors have been suggested, a systems level understanding of molecular pathomechanisms underlying this severe eye disorder is lacking. To address this gap in knowledge we performed the molecular level systems pathology analysis of the vitreous from 127 patients with RRD using state-of-the art quantitative mass spectrometry to identify the individual key proteins, as well as the biochemical pathways contributing to the development of the disease. RRD patients have specific vitreous proteome profiles compared to other diseases such as macular hole, pucker, or proliferative diabetic retinopathy eyes. Our data indicate that various mechanisms, including glycolysis, photoreceptor death, and Wnt and MAPK signaling, are activated during or after the RRD to promote retinal cell survival. In addition, platelet-mediated wound healing processes, cell adhesion molecules reorganization and apoptotic processes were detected during RRD progression or proliferative vitreoretinopathy formation. These findings improve the understanding of RRD pathogenesis, identify novel targets for treatment of this ophthalmic disease, and possibly affect the prognosis of eyes treated or operated upon due to RRD.Tiina ÖhmanLisa GawriyskiSini MiettinenMarkku VarjosaloSirpa LoukovaaraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tiina Öhman Lisa Gawriyski Sini Miettinen Markku Varjosalo Sirpa Loukovaara Molecular pathogenesis of rhegmatogenous retinal detachment
description	Abstract Rhegmatogenous retinal detachment (RRD) is an ophthalmic emergency, which usually requires prompt surgery to prevent further detachment and restore sensory function. Although several individual factors have been suggested, a systems level understanding of molecular pathomechanisms underlying this severe eye disorder is lacking. To address this gap in knowledge we performed the molecular level systems pathology analysis of the vitreous from 127 patients with RRD using state-of-the art quantitative mass spectrometry to identify the individual key proteins, as well as the biochemical pathways contributing to the development of the disease. RRD patients have specific vitreous proteome profiles compared to other diseases such as macular hole, pucker, or proliferative diabetic retinopathy eyes. Our data indicate that various mechanisms, including glycolysis, photoreceptor death, and Wnt and MAPK signaling, are activated during or after the RRD to promote retinal cell survival. In addition, platelet-mediated wound healing processes, cell adhesion molecules reorganization and apoptotic processes were detected during RRD progression or proliferative vitreoretinopathy formation. These findings improve the understanding of RRD pathogenesis, identify novel targets for treatment of this ophthalmic disease, and possibly affect the prognosis of eyes treated or operated upon due to RRD.
format	article
author	Tiina Öhman Lisa Gawriyski Sini Miettinen Markku Varjosalo Sirpa Loukovaara
author_facet	Tiina Öhman Lisa Gawriyski Sini Miettinen Markku Varjosalo Sirpa Loukovaara
author_sort	Tiina Öhman
title	Molecular pathogenesis of rhegmatogenous retinal detachment
title_short	Molecular pathogenesis of rhegmatogenous retinal detachment
title_full	Molecular pathogenesis of rhegmatogenous retinal detachment
title_fullStr	Molecular pathogenesis of rhegmatogenous retinal detachment
title_full_unstemmed	Molecular pathogenesis of rhegmatogenous retinal detachment
title_sort	molecular pathogenesis of rhegmatogenous retinal detachment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e531e06d2a9a4032bafd6a24e1e61c57
work_keys_str_mv	AT tiinaohman molecularpathogenesisofrhegmatogenousretinaldetachment AT lisagawriyski molecularpathogenesisofrhegmatogenousretinaldetachment AT sinimiettinen molecularpathogenesisofrhegmatogenousretinaldetachment AT markkuvarjosalo molecularpathogenesisofrhegmatogenousretinaldetachment AT sirpaloukovaara molecularpathogenesisofrhegmatogenousretinaldetachment
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Molecular pathogenesis of rhegmatogenous retinal detachment

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