Mitotic chromosome binding predicts transcription factor properties in interphase

Mammalian transcription factors (TFs) differ broadly in their DNA binding properties. Here authors quantify mitotic chromosome binding (MCB) of 501 TFs and suggest that MCB can be used as a proxy for non-specific TF-DNA interactions that regulate TF search for specific genomic sites.

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Autores principales:	Mahé Raccaud, Elias T. Friman, Andrea B. Alber, Harsha Agarwal, Cédric Deluz, Timo Kuhn, J. Christof M. Gebhardt, David M. Suter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e53314952b7e4610b9899ded05379f0d
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spelling	oai:doaj.org-article:e53314952b7e4610b9899ded05379f0d2021-12-02T15:35:34ZMitotic chromosome binding predicts transcription factor properties in interphase10.1038/s41467-019-08417-52041-1723https://doaj.org/article/e53314952b7e4610b9899ded05379f0d2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08417-5https://doaj.org/toc/2041-1723Mammalian transcription factors (TFs) differ broadly in their DNA binding properties. Here authors quantify mitotic chromosome binding (MCB) of 501 TFs and suggest that MCB can be used as a proxy for non-specific TF-DNA interactions that regulate TF search for specific genomic sites.Mahé RaccaudElias T. FrimanAndrea B. AlberHarsha AgarwalCédric DeluzTimo KuhnJ. Christof M. GebhardtDavid M. SuterNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mahé Raccaud Elias T. Friman Andrea B. Alber Harsha Agarwal Cédric Deluz Timo Kuhn J. Christof M. Gebhardt David M. Suter Mitotic chromosome binding predicts transcription factor properties in interphase
description	Mammalian transcription factors (TFs) differ broadly in their DNA binding properties. Here authors quantify mitotic chromosome binding (MCB) of 501 TFs and suggest that MCB can be used as a proxy for non-specific TF-DNA interactions that regulate TF search for specific genomic sites.
format	article
author	Mahé Raccaud Elias T. Friman Andrea B. Alber Harsha Agarwal Cédric Deluz Timo Kuhn J. Christof M. Gebhardt David M. Suter
author_facet	Mahé Raccaud Elias T. Friman Andrea B. Alber Harsha Agarwal Cédric Deluz Timo Kuhn J. Christof M. Gebhardt David M. Suter
author_sort	Mahé Raccaud
title	Mitotic chromosome binding predicts transcription factor properties in interphase
title_short	Mitotic chromosome binding predicts transcription factor properties in interphase
title_full	Mitotic chromosome binding predicts transcription factor properties in interphase
title_fullStr	Mitotic chromosome binding predicts transcription factor properties in interphase
title_full_unstemmed	Mitotic chromosome binding predicts transcription factor properties in interphase
title_sort	mitotic chromosome binding predicts transcription factor properties in interphase
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e53314952b7e4610b9899ded05379f0d
work_keys_str_mv	AT maheraccaud mitoticchromosomebindingpredictstranscriptionfactorpropertiesininterphase AT eliastfriman mitoticchromosomebindingpredictstranscriptionfactorpropertiesininterphase AT andreabalber mitoticchromosomebindingpredictstranscriptionfactorpropertiesininterphase AT harshaagarwal mitoticchromosomebindingpredictstranscriptionfactorpropertiesininterphase AT cedricdeluz mitoticchromosomebindingpredictstranscriptionfactorpropertiesininterphase AT timokuhn mitoticchromosomebindingpredictstranscriptionfactorpropertiesininterphase AT jchristofmgebhardt mitoticchromosomebindingpredictstranscriptionfactorpropertiesininterphase AT davidmsuter mitoticchromosomebindingpredictstranscriptionfactorpropertiesininterphase
_version_	1718386568275689472

Mitotic chromosome binding predicts transcription factor properties in interphase

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