Structural basis for adhesion G protein-coupled receptor Gpr126 function

The extracellular regions (ECRs) of adhesion GPCRs have diverse biological functions, but their structures and mechanisms of action remain unclear. Here, the authors solve the ECR structure of the Gpr126 receptor and show that ECR conformation and signaling functions are regulated by alternative spl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Katherine Leon, Rebecca L. Cunningham, Joshua A. Riback, Ezra Feldman, Jingxian Li, Tobin R. Sosnick, Minglei Zhao, Kelly R. Monk, Demet Araç
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e5359c615ebc4086814c00727386b7d8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e5359c615ebc4086814c00727386b7d8
record_format	dspace
spelling	oai:doaj.org-article:e5359c615ebc4086814c00727386b7d82021-12-02T17:31:24ZStructural basis for adhesion G protein-coupled receptor Gpr126 function10.1038/s41467-019-14040-12041-1723https://doaj.org/article/e5359c615ebc4086814c00727386b7d82020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14040-1https://doaj.org/toc/2041-1723The extracellular regions (ECRs) of adhesion GPCRs have diverse biological functions, but their structures and mechanisms of action remain unclear. Here, the authors solve the ECR structure of the Gpr126 receptor and show that ECR conformation and signaling functions are regulated by alternative splicing.Katherine LeonRebecca L. CunninghamJoshua A. RibackEzra FeldmanJingxian LiTobin R. SosnickMinglei ZhaoKelly R. MonkDemet AraçNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katherine Leon Rebecca L. Cunningham Joshua A. Riback Ezra Feldman Jingxian Li Tobin R. Sosnick Minglei Zhao Kelly R. Monk Demet Araç Structural basis for adhesion G protein-coupled receptor Gpr126 function
description	The extracellular regions (ECRs) of adhesion GPCRs have diverse biological functions, but their structures and mechanisms of action remain unclear. Here, the authors solve the ECR structure of the Gpr126 receptor and show that ECR conformation and signaling functions are regulated by alternative splicing.
format	article
author	Katherine Leon Rebecca L. Cunningham Joshua A. Riback Ezra Feldman Jingxian Li Tobin R. Sosnick Minglei Zhao Kelly R. Monk Demet Araç
author_facet	Katherine Leon Rebecca L. Cunningham Joshua A. Riback Ezra Feldman Jingxian Li Tobin R. Sosnick Minglei Zhao Kelly R. Monk Demet Araç
author_sort	Katherine Leon
title	Structural basis for adhesion G protein-coupled receptor Gpr126 function
title_short	Structural basis for adhesion G protein-coupled receptor Gpr126 function
title_full	Structural basis for adhesion G protein-coupled receptor Gpr126 function
title_fullStr	Structural basis for adhesion G protein-coupled receptor Gpr126 function
title_full_unstemmed	Structural basis for adhesion G protein-coupled receptor Gpr126 function
title_sort	structural basis for adhesion g protein-coupled receptor gpr126 function
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e5359c615ebc4086814c00727386b7d8
work_keys_str_mv	AT katherineleon structuralbasisforadhesiongproteincoupledreceptorgpr126function AT rebeccalcunningham structuralbasisforadhesiongproteincoupledreceptorgpr126function AT joshuaariback structuralbasisforadhesiongproteincoupledreceptorgpr126function AT ezrafeldman structuralbasisforadhesiongproteincoupledreceptorgpr126function AT jingxianli structuralbasisforadhesiongproteincoupledreceptorgpr126function AT tobinrsosnick structuralbasisforadhesiongproteincoupledreceptorgpr126function AT mingleizhao structuralbasisforadhesiongproteincoupledreceptorgpr126function AT kellyrmonk structuralbasisforadhesiongproteincoupledreceptorgpr126function AT demetarac structuralbasisforadhesiongproteincoupledreceptorgpr126function
_version_	1718380645675171840

Structural basis for adhesion G protein-coupled receptor Gpr126 function

Ejemplares similares