Alterations in erythrocyte membrane transporter expression levels in type 2 diabetic patients

Abstract Type 2 diabetes mellitus (T2DM) is one of the most common multifactorial diseases and several membrane transporters are involved in its development, complications and treatment. We have recently developed a flow-cytometry assay panel for the quantitative determination of red cell membrane p...

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Autores principales:	Edit Szabó, Anna Kulin, László Korányi, Botond Literáti-Nagy, Judit Cserepes, Anikó Somogyi, Balázs Sarkadi, György Várady
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e5369ce45b044a7c819cf6b39c05aeb1
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spelling	oai:doaj.org-article:e5369ce45b044a7c819cf6b39c05aeb12021-12-02T14:06:50ZAlterations in erythrocyte membrane transporter expression levels in type 2 diabetic patients10.1038/s41598-021-82417-82045-2322https://doaj.org/article/e5369ce45b044a7c819cf6b39c05aeb12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82417-8https://doaj.org/toc/2045-2322Abstract Type 2 diabetes mellitus (T2DM) is one of the most common multifactorial diseases and several membrane transporters are involved in its development, complications and treatment. We have recently developed a flow-cytometry assay panel for the quantitative determination of red cell membrane protein levels with potential relevance in diseases. Here we report a detailed phenotypic analysis of a medium scale, clinically based study on the expression of T2DM-related membrane proteins, the GLUT1, GLUT3, MCT1, URAT1, ABCA1, ABCG2 and the PMCA4 transporters in erythrocytes. By comparing age-matched control subjects and three groups of T2DM patients (recently diagnosed, successfully managed, and patients with disease-related complications), we found significant differences in the membrane expression levels of the transporters in these groups. This is a first detailed analysis of T2DM related alterations in erythrocyte membrane transporter protein levels, and the results suggest significant changes in some of the transporter expression levels in various patient groups. By performing a further, more detailed analysis of the clinical and molecular biology parameters, these data may serve as a basis of establishing new, personalized diagnostic markers helping the prevention and treatment of type 2 diabetes.Edit SzabóAnna KulinLászló KorányiBotond Literáti-NagyJudit CserepesAnikó SomogyiBalázs SarkadiGyörgy VáradyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Edit Szabó Anna Kulin László Korányi Botond Literáti-Nagy Judit Cserepes Anikó Somogyi Balázs Sarkadi György Várady Alterations in erythrocyte membrane transporter expression levels in type 2 diabetic patients
description	Abstract Type 2 diabetes mellitus (T2DM) is one of the most common multifactorial diseases and several membrane transporters are involved in its development, complications and treatment. We have recently developed a flow-cytometry assay panel for the quantitative determination of red cell membrane protein levels with potential relevance in diseases. Here we report a detailed phenotypic analysis of a medium scale, clinically based study on the expression of T2DM-related membrane proteins, the GLUT1, GLUT3, MCT1, URAT1, ABCA1, ABCG2 and the PMCA4 transporters in erythrocytes. By comparing age-matched control subjects and three groups of T2DM patients (recently diagnosed, successfully managed, and patients with disease-related complications), we found significant differences in the membrane expression levels of the transporters in these groups. This is a first detailed analysis of T2DM related alterations in erythrocyte membrane transporter protein levels, and the results suggest significant changes in some of the transporter expression levels in various patient groups. By performing a further, more detailed analysis of the clinical and molecular biology parameters, these data may serve as a basis of establishing new, personalized diagnostic markers helping the prevention and treatment of type 2 diabetes.
format	article
author	Edit Szabó Anna Kulin László Korányi Botond Literáti-Nagy Judit Cserepes Anikó Somogyi Balázs Sarkadi György Várady
author_facet	Edit Szabó Anna Kulin László Korányi Botond Literáti-Nagy Judit Cserepes Anikó Somogyi Balázs Sarkadi György Várady
author_sort	Edit Szabó
title	Alterations in erythrocyte membrane transporter expression levels in type 2 diabetic patients
title_short	Alterations in erythrocyte membrane transporter expression levels in type 2 diabetic patients
title_full	Alterations in erythrocyte membrane transporter expression levels in type 2 diabetic patients
title_fullStr	Alterations in erythrocyte membrane transporter expression levels in type 2 diabetic patients
title_full_unstemmed	Alterations in erythrocyte membrane transporter expression levels in type 2 diabetic patients
title_sort	alterations in erythrocyte membrane transporter expression levels in type 2 diabetic patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e5369ce45b044a7c819cf6b39c05aeb1
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Alterations in erythrocyte membrane transporter expression levels in type 2 diabetic patients

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