Attention deficits in Japanese multiple sclerosis patients with minor brain lesion loads

Akitoshi Takeda1,3, Masashi Nakajima1, Mutsutaka Kobayakawa1, Natsuko Tsuruya1, Shin-ichi Koyama1,2, Takami Miki3, Mitsuru Kawamura1,41Department of Neurology, Showa University School of Medicine, Tokyo, Japan; 2Faculty of Engineering, Chiba University, Chiba, Japan; 3Department of Geriatric Medicin...

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Autores principales:	Takeda A, Nakajima M, Kobayakawa M, Tsuruya N, Koyama S, Miki T, Kawamura M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e53e862b29ae4a308e134b1857eeb1ec
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spelling	oai:doaj.org-article:e53e862b29ae4a308e134b1857eeb1ec2021-12-02T04:55:24ZAttention deficits in Japanese multiple sclerosis patients with minor brain lesion loads1176-63281178-2021https://doaj.org/article/e53e862b29ae4a308e134b1857eeb1ec2011-12-01T00:00:00Zhttp://www.dovepress.com/attention-deficits-in-japanese-multiple-sclerosis-patients-with-minor--a8893https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Akitoshi Takeda1,3, Masashi Nakajima1, Mutsutaka Kobayakawa1, Natsuko Tsuruya1, Shin-ichi Koyama1,2, Takami Miki3, Mitsuru Kawamura1,41Department of Neurology, Showa University School of Medicine, Tokyo, Japan; 2Faculty of Engineering, Chiba University, Chiba, Japan; 3Department of Geriatric Medicine and Neurology, Osaka City University Graduate School of Medicine, Osaka, Japan; 4Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Saitama, JapanBackground: To investigate whether Japanese multiple sclerosis (MS) patients with minor brain lesion loads have attention deficits and brain atrophy, and to correlate their circumstance.Method: Twenty-one Japanese patients with relapsing-remitting MS were included in this study. Attention deficits were evaluated using Clinical Assessment for Attention (CAT) standardized according to age groups. Lesion load in the brain was assessed by tallying the total volume of plaques visible on brain magnetic resonance imaging (MRI). The width of the third ventricle and the bicaudate ratio were measured.Results: The completion time for the visual cancellation tasks and/or the reaction times for the continuous performance test were prolonged in 14 patients (66.7%). The accuracy of responses was preserved throughout the CAT. Deviation from the normal value was not exaggerated based on the increasing difficulty of the task. The total volume of plaques on brain MRI was small. The width of the third ventricle was significantly increased in patients with MS when compared to controls, but was not correlated with the low performance on the CAT.Conclusions: Japanese MS patients with minor brain lesion loads frequently had attention deficits characterized by slowness of automatic information processing, but controlled processing that requires working memory demands was spared.Keywords: attention, cognitive function, magnetic resonance imaging, multiple sclerosisTakeda ANakajima MKobayakawa MTsuruya NKoyama SMiki TKawamura MDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2011, Iss Issue 1, Pp 745-751 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Takeda A Nakajima M Kobayakawa M Tsuruya N Koyama S Miki T Kawamura M Attention deficits in Japanese multiple sclerosis patients with minor brain lesion loads
description	Akitoshi Takeda1,3, Masashi Nakajima1, Mutsutaka Kobayakawa1, Natsuko Tsuruya1, Shin-ichi Koyama1,2, Takami Miki3, Mitsuru Kawamura1,41Department of Neurology, Showa University School of Medicine, Tokyo, Japan; 2Faculty of Engineering, Chiba University, Chiba, Japan; 3Department of Geriatric Medicine and Neurology, Osaka City University Graduate School of Medicine, Osaka, Japan; 4Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Saitama, JapanBackground: To investigate whether Japanese multiple sclerosis (MS) patients with minor brain lesion loads have attention deficits and brain atrophy, and to correlate their circumstance.Method: Twenty-one Japanese patients with relapsing-remitting MS were included in this study. Attention deficits were evaluated using Clinical Assessment for Attention (CAT) standardized according to age groups. Lesion load in the brain was assessed by tallying the total volume of plaques visible on brain magnetic resonance imaging (MRI). The width of the third ventricle and the bicaudate ratio were measured.Results: The completion time for the visual cancellation tasks and/or the reaction times for the continuous performance test were prolonged in 14 patients (66.7%). The accuracy of responses was preserved throughout the CAT. Deviation from the normal value was not exaggerated based on the increasing difficulty of the task. The total volume of plaques on brain MRI was small. The width of the third ventricle was significantly increased in patients with MS when compared to controls, but was not correlated with the low performance on the CAT.Conclusions: Japanese MS patients with minor brain lesion loads frequently had attention deficits characterized by slowness of automatic information processing, but controlled processing that requires working memory demands was spared.Keywords: attention, cognitive function, magnetic resonance imaging, multiple sclerosis
format	article
author	Takeda A Nakajima M Kobayakawa M Tsuruya N Koyama S Miki T Kawamura M
author_facet	Takeda A Nakajima M Kobayakawa M Tsuruya N Koyama S Miki T Kawamura M
author_sort	Takeda A
title	Attention deficits in Japanese multiple sclerosis patients with minor brain lesion loads
title_short	Attention deficits in Japanese multiple sclerosis patients with minor brain lesion loads
title_full	Attention deficits in Japanese multiple sclerosis patients with minor brain lesion loads
title_fullStr	Attention deficits in Japanese multiple sclerosis patients with minor brain lesion loads
title_full_unstemmed	Attention deficits in Japanese multiple sclerosis patients with minor brain lesion loads
title_sort	attention deficits in japanese multiple sclerosis patients with minor brain lesion loads
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/e53e862b29ae4a308e134b1857eeb1ec
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Attention deficits in Japanese multiple sclerosis patients with minor brain lesion loads

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