Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae

Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae

Therapeutics to combat multidrug-resistant bacteria such as Klebsiella pneumoniae are needed. Here the authors show immune evasion drives lipopolysaccharide O2 serotype expansion in multidrug-resistant isolates, and anti-O-antigen human monoclonal antibodies synergize with antibiotics to protect mic...

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Autores principales: Meghan E. Pennini, Anna De Marco, Mark Pelletier, Jessica Bonnell, Romana Cvitkovic, Martina Beltramello, Elisabetta Cameroni, Siro Bianchi, Fabrizia Zatta, Wei Zhao, Xiaodong Xiao, Maria M. Camara, Antonio DiGiandomenico, Elena Semenova, Antonio Lanzavecchia, Paul Warrener, JoAnn Suzich, Qun Wang, Davide Corti, C. Kendall Stover
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/e53fb32687cc4941aa9b9d884dee44c8
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spelling oai:doaj.org-article:e53fb32687cc4941aa9b9d884dee44c82021-12-02T17:01:22ZImmune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae10.1038/s41467-017-02223-72041-1723https://doaj.org/article/e53fb32687cc4941aa9b9d884dee44c82017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02223-7https://doaj.org/toc/2041-1723Therapeutics to combat multidrug-resistant bacteria such as Klebsiella pneumoniae are needed. Here the authors show immune evasion drives lipopolysaccharide O2 serotype expansion in multidrug-resistant isolates, and anti-O-antigen human monoclonal antibodies synergize with antibiotics to protect mice from infection.Meghan E. PenniniAnna De MarcoMark PelletierJessica BonnellRomana CvitkovicMartina BeltramelloElisabetta CameroniSiro BianchiFabrizia ZattaWei ZhaoXiaodong XiaoMaria M. CamaraAntonio DiGiandomenicoElena SemenovaAntonio LanzavecchiaPaul WarrenerJoAnn SuzichQun WangDavide CortiC. Kendall StoverNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Meghan E. Pennini
Anna De Marco
Mark Pelletier
Jessica Bonnell
Romana Cvitkovic
Martina Beltramello
Elisabetta Cameroni
Siro Bianchi
Fabrizia Zatta
Wei Zhao
Xiaodong Xiao
Maria M. Camara
Antonio DiGiandomenico
Elena Semenova
Antonio Lanzavecchia
Paul Warrener
JoAnn Suzich
Qun Wang
Davide Corti
C. Kendall Stover
Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae
description Therapeutics to combat multidrug-resistant bacteria such as Klebsiella pneumoniae are needed. Here the authors show immune evasion drives lipopolysaccharide O2 serotype expansion in multidrug-resistant isolates, and anti-O-antigen human monoclonal antibodies synergize with antibiotics to protect mice from infection.
format article
author Meghan E. Pennini
Anna De Marco
Mark Pelletier
Jessica Bonnell
Romana Cvitkovic
Martina Beltramello
Elisabetta Cameroni
Siro Bianchi
Fabrizia Zatta
Wei Zhao
Xiaodong Xiao
Maria M. Camara
Antonio DiGiandomenico
Elena Semenova
Antonio Lanzavecchia
Paul Warrener
JoAnn Suzich
Qun Wang
Davide Corti
C. Kendall Stover
author_facet Meghan E. Pennini
Anna De Marco
Mark Pelletier
Jessica Bonnell
Romana Cvitkovic
Martina Beltramello
Elisabetta Cameroni
Siro Bianchi
Fabrizia Zatta
Wei Zhao
Xiaodong Xiao
Maria M. Camara
Antonio DiGiandomenico
Elena Semenova
Antonio Lanzavecchia
Paul Warrener
JoAnn Suzich
Qun Wang
Davide Corti
C. Kendall Stover
author_sort Meghan E. Pennini
title Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae
title_short Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae
title_full Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae
title_fullStr Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae
title_full_unstemmed Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae
title_sort immune stealth-driven o2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant klebsiella pneumoniae
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/e53fb32687cc4941aa9b9d884dee44c8
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