Carbene footprinting accurately maps binding sites in protein–ligand and protein–protein interactions

Mapping protein-ligand interactions is fundamental to advance the understanding of cellular processes and to develop drug discovery strategies. Here, the authors present a photo-activated probe that allows highly efficient labelling and identification of protein binding sites using mass spectrometry...

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Bibliographic Details
Main Authors: Lucio Manzi, Andrew S. Barrow, Daniel Scott, Robert Layfield, Timothy G. Wright, John E. Moses, Neil J. Oldham
Format: article
Language:EN
Published: Nature Portfolio 2016
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Online Access:https://doaj.org/article/e5438de36b074b1c86bc4b655e92a87c
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