A novel RNA-mediated mechanism causing down-regulation of insulating promoter interactions in human embryonic stem cells

A novel RNA-mediated mechanism causing down-regulation of insulating promoter interactions in human embryonic stem cells

Abstract The genome-wide promoter interactome is primarily maintained and regulated by architectural proteins such as CTCF and cohesin. However, some studies suggest a role for non-coding RNAs (ncRNAs) in this process. We aimed to characterise the regulatory role of RNA-mediated promoter interaction...

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Autores principales: Yingjuan Liu, Simon G. Williams, Hayden R. Jones, Bernard D. Keavney, Mun-Kit Choy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e549fe2048b642deb926b19e627cea3f
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