The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients

Abstract To explore the value, and influencing factors, of D-dimer on the prognosis of patients with COVID-19. A total of 1,114 patients with confirmed COVID-19 who were admitted to three designated COVID-19 hospitals in Wuhan, China from January 18, 2020, to March 24, 2020, were included in this st...

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Autores principales:	Xiaokang He, Fei Yao, Jie Chen, Yan Wang, Xiangming Fang, Xuan Lin, Hui Long, Qiang Wang, Qingming Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e54a2a6654504f8fa436ca9fb1598d44
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spelling	oai:doaj.org-article:e54a2a6654504f8fa436ca9fb1598d442021-12-02T14:09:01ZThe poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients10.1038/s41598-021-81300-w2045-2322https://doaj.org/article/e54a2a6654504f8fa436ca9fb1598d442021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81300-whttps://doaj.org/toc/2045-2322Abstract To explore the value, and influencing factors, of D-dimer on the prognosis of patients with COVID-19. A total of 1,114 patients with confirmed COVID-19 who were admitted to three designated COVID-19 hospitals in Wuhan, China from January 18, 2020, to March 24, 2020, were included in this study. We examined the relationship between peripheral blood levels of D-dimer, and clinical classification and prognosis, as well as its related influencing factors. D-dimer levels were found to be related to the clinical classification and the prognosis of clinical outcome. D-dimer levels were more likely to be abnormal in severely and critically ill patients compared with mild and ordinary cases, while D-dimer levels of patients who had died were significantly higher than those of surviving patients according to the results of the first and last lab tests. The results from ROC analyses for mortality risk showed that the AUCs of D-dimer were 0.909, YI was 0.765 at the last lab test, and a D-dimer value of 2.025 mg/L was regarded to be the optimal probability cutoff for a prognosis of death. In addition, we found that patients with advanced age, male gender, dyspnea symptoms, and some underlying diseases have a higher D-dimer value (p < 0.05). In short, D-dimer is related to the clinical classification and can be used to evaluate the prognosis of COVID-19 patients. The D-dimer value of 2.025 mg/L was the optimal probability cutoff for judging an outcome of death. Advanced age, male gender, dyspnea symptoms, and some underlying diseases are influencing factors for D-dimer levels, which impacts the prognosis of patients.Xiaokang HeFei YaoJie ChenYan WangXiangming FangXuan LinHui LongQiang WangQingming WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaokang He Fei Yao Jie Chen Yan Wang Xiangming Fang Xuan Lin Hui Long Qiang Wang Qingming Wu The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients
description	Abstract To explore the value, and influencing factors, of D-dimer on the prognosis of patients with COVID-19. A total of 1,114 patients with confirmed COVID-19 who were admitted to three designated COVID-19 hospitals in Wuhan, China from January 18, 2020, to March 24, 2020, were included in this study. We examined the relationship between peripheral blood levels of D-dimer, and clinical classification and prognosis, as well as its related influencing factors. D-dimer levels were found to be related to the clinical classification and the prognosis of clinical outcome. D-dimer levels were more likely to be abnormal in severely and critically ill patients compared with mild and ordinary cases, while D-dimer levels of patients who had died were significantly higher than those of surviving patients according to the results of the first and last lab tests. The results from ROC analyses for mortality risk showed that the AUCs of D-dimer were 0.909, YI was 0.765 at the last lab test, and a D-dimer value of 2.025 mg/L was regarded to be the optimal probability cutoff for a prognosis of death. In addition, we found that patients with advanced age, male gender, dyspnea symptoms, and some underlying diseases have a higher D-dimer value (p < 0.05). In short, D-dimer is related to the clinical classification and can be used to evaluate the prognosis of COVID-19 patients. The D-dimer value of 2.025 mg/L was the optimal probability cutoff for judging an outcome of death. Advanced age, male gender, dyspnea symptoms, and some underlying diseases are influencing factors for D-dimer levels, which impacts the prognosis of patients.
format	article
author	Xiaokang He Fei Yao Jie Chen Yan Wang Xiangming Fang Xuan Lin Hui Long Qiang Wang Qingming Wu
author_facet	Xiaokang He Fei Yao Jie Chen Yan Wang Xiangming Fang Xuan Lin Hui Long Qiang Wang Qingming Wu
author_sort	Xiaokang He
title	The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients
title_short	The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients
title_full	The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients
title_fullStr	The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients
title_full_unstemmed	The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients
title_sort	poor prognosis and influencing factors of high d-dimer levels for covid-19 patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e54a2a6654504f8fa436ca9fb1598d44
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The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients

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