A Systematic Survey of Characteristic Features of Yeast Cell Death Triggered by External Factors

Cell death in response to distinct stimuli can manifest different morphological traits. It also depends on various cell death signaling pathways, extensively characterized in higher eukaryotes but less so in microorganisms. The study of cell death in yeast, and specifically <i>Saccharomyces ce...

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Autores principales:	Erika V. Grosfeld, Victoria A. Bidiuk, Olga V. Mitkevich, Eslam S. M. O. Ghazy, Vitaliy V. Kushnirov, Alexander I. Alexandrov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	death yeast necrosis apoptosis autophagy viability Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e54b56a746f94ad18f358f1d5f5cc011
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id	oai:doaj.org-article:e54b56a746f94ad18f358f1d5f5cc011
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spelling	oai:doaj.org-article:e54b56a746f94ad18f358f1d5f5cc0112021-11-25T18:05:27ZA Systematic Survey of Characteristic Features of Yeast Cell Death Triggered by External Factors10.3390/jof71108862309-608Xhttps://doaj.org/article/e54b56a746f94ad18f358f1d5f5cc0112021-10-01T00:00:00Zhttps://www.mdpi.com/2309-608X/7/11/886https://doaj.org/toc/2309-608XCell death in response to distinct stimuli can manifest different morphological traits. It also depends on various cell death signaling pathways, extensively characterized in higher eukaryotes but less so in microorganisms. The study of cell death in yeast, and specifically <i>Saccharomyces cerevisiae</i>, can potentially be productive for understanding cell death, since numerous killing stimuli have been characterized for this organism. Here, we systematized the literature on external treatments that kill yeast, and which contains at least minimal data on cell death mechanisms. Data from 707 papers from the 7000 obtained using keyword searches were used to create a reference table for filtering types of cell death according to commonly assayed parameters. This table provides a resource for orientation within the literature; however, it also highlights that the common view of similarity between non-necrotic death in yeast and apoptosis in mammals has not provided sufficient progress to create a clear classification of cell death types. Differences in experimental setups also prevent direct comparison between different stimuli. Thus, side-by-side comparisons of various cell death-inducing stimuli under comparable conditions using existing and novel markers that can differentiate between types of cell death seem like a promising direction for future studies.Erika V. GrosfeldVictoria A. BidiukOlga V. MitkevichEslam S. M. O. GhazyVitaliy V. KushnirovAlexander I. AlexandrovMDPI AGarticledeathyeastnecrosisapoptosisautophagyviabilityBiology (General)QH301-705.5ENJournal of Fungi, Vol 7, Iss 886, p 886 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	death yeast necrosis apoptosis autophagy viability Biology (General) QH301-705.5
spellingShingle	death yeast necrosis apoptosis autophagy viability Biology (General) QH301-705.5 Erika V. Grosfeld Victoria A. Bidiuk Olga V. Mitkevich Eslam S. M. O. Ghazy Vitaliy V. Kushnirov Alexander I. Alexandrov A Systematic Survey of Characteristic Features of Yeast Cell Death Triggered by External Factors
description	Cell death in response to distinct stimuli can manifest different morphological traits. It also depends on various cell death signaling pathways, extensively characterized in higher eukaryotes but less so in microorganisms. The study of cell death in yeast, and specifically <i>Saccharomyces cerevisiae</i>, can potentially be productive for understanding cell death, since numerous killing stimuli have been characterized for this organism. Here, we systematized the literature on external treatments that kill yeast, and which contains at least minimal data on cell death mechanisms. Data from 707 papers from the 7000 obtained using keyword searches were used to create a reference table for filtering types of cell death according to commonly assayed parameters. This table provides a resource for orientation within the literature; however, it also highlights that the common view of similarity between non-necrotic death in yeast and apoptosis in mammals has not provided sufficient progress to create a clear classification of cell death types. Differences in experimental setups also prevent direct comparison between different stimuli. Thus, side-by-side comparisons of various cell death-inducing stimuli under comparable conditions using existing and novel markers that can differentiate between types of cell death seem like a promising direction for future studies.
format	article
author	Erika V. Grosfeld Victoria A. Bidiuk Olga V. Mitkevich Eslam S. M. O. Ghazy Vitaliy V. Kushnirov Alexander I. Alexandrov
author_facet	Erika V. Grosfeld Victoria A. Bidiuk Olga V. Mitkevich Eslam S. M. O. Ghazy Vitaliy V. Kushnirov Alexander I. Alexandrov
author_sort	Erika V. Grosfeld
title	A Systematic Survey of Characteristic Features of Yeast Cell Death Triggered by External Factors
title_short	A Systematic Survey of Characteristic Features of Yeast Cell Death Triggered by External Factors
title_full	A Systematic Survey of Characteristic Features of Yeast Cell Death Triggered by External Factors
title_fullStr	A Systematic Survey of Characteristic Features of Yeast Cell Death Triggered by External Factors
title_full_unstemmed	A Systematic Survey of Characteristic Features of Yeast Cell Death Triggered by External Factors
title_sort	systematic survey of characteristic features of yeast cell death triggered by external factors
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e54b56a746f94ad18f358f1d5f5cc011
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A Systematic Survey of Characteristic Features of Yeast Cell Death Triggered by External Factors

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