Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma

Abstract Cathepsin A (CTSA) is a lysosomal protease that regulates galactoside metabolism. The previous study has shown CTSA is abnormally expressed in various types of cancer. However, rarely the previous study has addressed the role of CTSA in hepatocellular carcinoma (HCC) and its prognostic valu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Huaxiang Wang, Fengfeng Xu, Fang Yang, Lizhi Lv, Yi Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e54e18f14ae344f3a25729d286f77238
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e54e18f14ae344f3a25729d286f77238
record_format	dspace
spelling	oai:doaj.org-article:e54e18f14ae344f3a25729d286f772382021-12-02T16:14:16ZPrognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma10.1038/s41598-021-93998-92045-2322https://doaj.org/article/e54e18f14ae344f3a25729d286f772382021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93998-9https://doaj.org/toc/2045-2322Abstract Cathepsin A (CTSA) is a lysosomal protease that regulates galactoside metabolism. The previous study has shown CTSA is abnormally expressed in various types of cancer. However, rarely the previous study has addressed the role of CTSA in hepatocellular carcinoma (HCC) and its prognostic value. To study the clinical value and potential function of CTSA in HCC, datasets from the Cancer Genome Atlas (TCGA) database and a 136 HCC patient cohort were analyzed. CTSA expression was found to be significantly higher in HCC patients compared with normal liver tissues, which was supported by immunohistochemistry (IHC) validation. Both gene ontology (GO) and The Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses demonstrated that CTSA co-expressed genes were involved in ATP hydrolysis coupled proton transport, carbohydrate metabolic process, lysosome organization, oxidative phosphorylation, other glycan degradation, etc. Survival analysis showed a significant reduction both in overall survival (OS) and recurrence-free survival (RFS) of patients with high CTSA expression from both the TCGA HCC cohort and 136 patients with the HCC cohort. Furthermore, CTSA overexpression has diagnostic value in distinguishing between HCC and normal liver tissue [Area under curve (AUC) = 0.864]. Moreover, Gene set enrichment analysis (GSEA) showed that CTSA expression correlated with the oxidative phosphorylation, proteasome, and lysosome, etc. in HCC tissues. These findings demonstrate that CTSA may as a potential diagnostic and prognostic biomarker in HCC.Huaxiang WangFengfeng XuFang YangLizhi LvYi JiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huaxiang Wang Fengfeng Xu Fang Yang Lizhi Lv Yi Jiang Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma
description	Abstract Cathepsin A (CTSA) is a lysosomal protease that regulates galactoside metabolism. The previous study has shown CTSA is abnormally expressed in various types of cancer. However, rarely the previous study has addressed the role of CTSA in hepatocellular carcinoma (HCC) and its prognostic value. To study the clinical value and potential function of CTSA in HCC, datasets from the Cancer Genome Atlas (TCGA) database and a 136 HCC patient cohort were analyzed. CTSA expression was found to be significantly higher in HCC patients compared with normal liver tissues, which was supported by immunohistochemistry (IHC) validation. Both gene ontology (GO) and The Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses demonstrated that CTSA co-expressed genes were involved in ATP hydrolysis coupled proton transport, carbohydrate metabolic process, lysosome organization, oxidative phosphorylation, other glycan degradation, etc. Survival analysis showed a significant reduction both in overall survival (OS) and recurrence-free survival (RFS) of patients with high CTSA expression from both the TCGA HCC cohort and 136 patients with the HCC cohort. Furthermore, CTSA overexpression has diagnostic value in distinguishing between HCC and normal liver tissue [Area under curve (AUC) = 0.864]. Moreover, Gene set enrichment analysis (GSEA) showed that CTSA expression correlated with the oxidative phosphorylation, proteasome, and lysosome, etc. in HCC tissues. These findings demonstrate that CTSA may as a potential diagnostic and prognostic biomarker in HCC.
format	article
author	Huaxiang Wang Fengfeng Xu Fang Yang Lizhi Lv Yi Jiang
author_facet	Huaxiang Wang Fengfeng Xu Fang Yang Lizhi Lv Yi Jiang
author_sort	Huaxiang Wang
title	Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma
title_short	Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma
title_full	Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma
title_fullStr	Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma
title_full_unstemmed	Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma
title_sort	prognostic significance and oncogene function of cathepsin a in hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e54e18f14ae344f3a25729d286f77238
work_keys_str_mv	AT huaxiangwang prognosticsignificanceandoncogenefunctionofcathepsinainhepatocellularcarcinoma AT fengfengxu prognosticsignificanceandoncogenefunctionofcathepsinainhepatocellularcarcinoma AT fangyang prognosticsignificanceandoncogenefunctionofcathepsinainhepatocellularcarcinoma AT lizhilv prognosticsignificanceandoncogenefunctionofcathepsinainhepatocellularcarcinoma AT yijiang prognosticsignificanceandoncogenefunctionofcathepsinainhepatocellularcarcinoma
_version_	1718384382330273792

Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma

Ejemplares similares