Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition

Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition

Peipei Xu,1 Jingyuan Li,2 Lixin Shi,3 Matthias Selke,3 Baoan Chen,4 Xuemei Wang5 1Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China; 2Laboratory Animal Center, Institute of Comparative Medicine, Nantong Un...

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Autores principales: Xu P, Li J, Shi L, Selke M, Chen B, Wang X
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/e550a4c047ea408dbfcefb1d248a65f1
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spelling oai:doaj.org-article:e550a4c047ea408dbfcefb1d248a65f12021-12-02T08:07:38ZSynergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition1176-91141178-2013https://doaj.org/article/e550a4c047ea408dbfcefb1d248a65f12013-09-01T00:00:00Zhttp://www.dovepress.com/synergetic-effect-of-functional-cadmiumndashtellurium-quantum-dots-con-a14523https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Peipei Xu,1 Jingyuan Li,2 Lixin Shi,3 Matthias Selke,3 Baoan Chen,4 Xuemei Wang5 1Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China; 2Laboratory Animal Center, Institute of Comparative Medicine, Nantong University, Nantong, People’s Republic of China; 3Department of Chemistry and Biochemistry, California State University – Los Angeles, Los Angeles, CA, USA; 4Department of Hematology, Zhongda Hospital, Southeast University, Nanjing, People’s Republic of China; 5State Key Lab of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing, People’s Republic of ChinaAbstract: We prepared and studied novel fluorescent nanocomposites based on gambogic acid (GA) and cadmium–tellurium (CdTe) quantum dots (CdTe QDs) modified with cysteamine for purpose of cancer cell labeling and combined treatment. The nanocomposites were denoted as GA-CdTe. Characterization results indicated that the CdTe QDs can readily bind onto cell plasma membranes and then be internalized into cancer cells for real-time labeling and tracing of human liver hepatocellular carcinoma cell line (HepG2) cells. GA-CdTe significantly enhanced drug accumulation in HepG2 cells and inhibited cancer cell proliferation. GA-CdTe nanocomposites also improved the drug action of GA molecules in HepG2 cells and induced the G2/M phase arrest of the cancer cell cycle, promoting cell apoptosis. Given the sensitive, pH-triggered release of GA-CdTe, the side effects of GA anticancer agents on normal cells/tissues in the blood circulation markedly decreased. Efficient drug release and accumulation in target tumor cells were also facilitated. Thus, the fluorescent GA-CdTe offered a new strategy for potential multimode cancer therapy and provided new channels for research into naturally-active compounds extracted from traditional Chinese medicinal plants.Keywords: cadmium-tellurium quantum dots, gambogic acid, drug delivery, cell labeling, therapyXu PLi JShi LSelke MChen BWang XDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 3729-3736 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Xu P
Li J
Shi L
Selke M
Chen B
Wang X
Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition
description Peipei Xu,1 Jingyuan Li,2 Lixin Shi,3 Matthias Selke,3 Baoan Chen,4 Xuemei Wang5 1Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China; 2Laboratory Animal Center, Institute of Comparative Medicine, Nantong University, Nantong, People’s Republic of China; 3Department of Chemistry and Biochemistry, California State University – Los Angeles, Los Angeles, CA, USA; 4Department of Hematology, Zhongda Hospital, Southeast University, Nanjing, People’s Republic of China; 5State Key Lab of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing, People’s Republic of ChinaAbstract: We prepared and studied novel fluorescent nanocomposites based on gambogic acid (GA) and cadmium–tellurium (CdTe) quantum dots (CdTe QDs) modified with cysteamine for purpose of cancer cell labeling and combined treatment. The nanocomposites were denoted as GA-CdTe. Characterization results indicated that the CdTe QDs can readily bind onto cell plasma membranes and then be internalized into cancer cells for real-time labeling and tracing of human liver hepatocellular carcinoma cell line (HepG2) cells. GA-CdTe significantly enhanced drug accumulation in HepG2 cells and inhibited cancer cell proliferation. GA-CdTe nanocomposites also improved the drug action of GA molecules in HepG2 cells and induced the G2/M phase arrest of the cancer cell cycle, promoting cell apoptosis. Given the sensitive, pH-triggered release of GA-CdTe, the side effects of GA anticancer agents on normal cells/tissues in the blood circulation markedly decreased. Efficient drug release and accumulation in target tumor cells were also facilitated. Thus, the fluorescent GA-CdTe offered a new strategy for potential multimode cancer therapy and provided new channels for research into naturally-active compounds extracted from traditional Chinese medicinal plants.Keywords: cadmium-tellurium quantum dots, gambogic acid, drug delivery, cell labeling, therapy
format article
author Xu P
Li J
Shi L
Selke M
Chen B
Wang X
author_facet Xu P
Li J
Shi L
Selke M
Chen B
Wang X
author_sort Xu P
title Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition
title_short Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition
title_full Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition
title_fullStr Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition
title_full_unstemmed Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition
title_sort synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for hepg2 cell-labeling and proliferation inhibition
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/e550a4c047ea408dbfcefb1d248a65f1
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AT shil synergeticeffectoffunctionalcadmiumndashtelluriumquantumdotsconjugatedwithgambogicacidforhepg2celllabelingandproliferationinhibition
AT selkem synergeticeffectoffunctionalcadmiumndashtelluriumquantumdotsconjugatedwithgambogicacidforhepg2celllabelingandproliferationinhibition
AT chenb synergeticeffectoffunctionalcadmiumndashtelluriumquantumdotsconjugatedwithgambogicacidforhepg2celllabelingandproliferationinhibition
AT wangx synergeticeffectoffunctionalcadmiumndashtelluriumquantumdotsconjugatedwithgambogicacidforhepg2celllabelingandproliferationinhibition
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