XPO5 promotes primary miRNA processing independently of RanGTP

XPO5 promotes primary miRNA processing independently of RanGTP

XPO5 mediates nuclear export of miRNA hairpin precursors (pre-miRNAs) through a RanGTP-dependent binding. Here the authors employ HITS-CLIP and biochemical analysis and show that XPO5 binds and promotes nuclear processing of clustered pri-miRNAs, with extensive double-stranded regions, independently...

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Autores principales: Jingjing Wang, Jerome E. Lee, Kent Riemondy, Yang Yu, Steven M. Marquez, Eric C. Lai, Rui Yi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/e5599e5636e1449f8fedcdac30d97247
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spelling oai:doaj.org-article:e5599e5636e1449f8fedcdac30d972472021-12-02T14:41:03ZXPO5 promotes primary miRNA processing independently of RanGTP10.1038/s41467-020-15598-x2041-1723https://doaj.org/article/e5599e5636e1449f8fedcdac30d972472020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15598-xhttps://doaj.org/toc/2041-1723XPO5 mediates nuclear export of miRNA hairpin precursors (pre-miRNAs) through a RanGTP-dependent binding. Here the authors employ HITS-CLIP and biochemical analysis and show that XPO5 binds and promotes nuclear processing of clustered pri-miRNAs, with extensive double-stranded regions, independently of RanGTP.Jingjing WangJerome E. LeeKent RiemondyYang YuSteven M. MarquezEric C. LaiRui YiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jingjing Wang
Jerome E. Lee
Kent Riemondy
Yang Yu
Steven M. Marquez
Eric C. Lai
Rui Yi
XPO5 promotes primary miRNA processing independently of RanGTP
description XPO5 mediates nuclear export of miRNA hairpin precursors (pre-miRNAs) through a RanGTP-dependent binding. Here the authors employ HITS-CLIP and biochemical analysis and show that XPO5 binds and promotes nuclear processing of clustered pri-miRNAs, with extensive double-stranded regions, independently of RanGTP.
format article
author Jingjing Wang
Jerome E. Lee
Kent Riemondy
Yang Yu
Steven M. Marquez
Eric C. Lai
Rui Yi
author_facet Jingjing Wang
Jerome E. Lee
Kent Riemondy
Yang Yu
Steven M. Marquez
Eric C. Lai
Rui Yi
author_sort Jingjing Wang
title XPO5 promotes primary miRNA processing independently of RanGTP
title_short XPO5 promotes primary miRNA processing independently of RanGTP
title_full XPO5 promotes primary miRNA processing independently of RanGTP
title_fullStr XPO5 promotes primary miRNA processing independently of RanGTP
title_full_unstemmed XPO5 promotes primary miRNA processing independently of RanGTP
title_sort xpo5 promotes primary mirna processing independently of rangtp
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/e5599e5636e1449f8fedcdac30d97247
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AT kentriemondy xpo5promotesprimarymirnaprocessingindependentlyofrangtp
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AT stevenmmarquez xpo5promotesprimarymirnaprocessingindependentlyofrangtp
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