Relationship Between Plasma Total Homocysteine Levels and Mean Corrected TIMI Frame Count in Patients with Acute Myocardial Infarction

Feng Hu,1 Feng Lu,2 Xiao Huang,1 Xiaoshu Cheng1 1The Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 2The Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, People’...

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Autores principales:	Hu F, Lu F, Huang X, Cheng X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hyperhomocysteinemia mean corrected timi frame count acute myocardial infarction slow coronary flow coronary microcirculation dysfunction. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e559cddea1b14dbfa1eefb82ccd82d3d
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spelling	oai:doaj.org-article:e559cddea1b14dbfa1eefb82ccd82d3d2021-11-16T18:47:50ZRelationship Between Plasma Total Homocysteine Levels and Mean Corrected TIMI Frame Count in Patients with Acute Myocardial Infarction1178-7074https://doaj.org/article/e559cddea1b14dbfa1eefb82ccd82d3d2021-11-01T00:00:00Zhttps://www.dovepress.com/relationship-between-plasma-total-homocysteine-levels-and-mean-correct-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Feng Hu,1 Feng Lu,2 Xiao Huang,1 Xiaoshu Cheng1 1The Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 2The Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of ChinaCorrespondence: Xiao Huang; Xiaoshu ChengDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330006, Jiangxi, People’s Republic of ChinaTel +8613607089128Fax +86-791-86262262Email drxiaohuang@163.com; xiaoshumenfan126@163.comObjective: To explore the relationship between the plasma total homocysteine (tHcy) levels and slow coronary flow (SCF) measured by mean corrected TIMI frame count (CTFC) in patients with acute myocardial infarction (AMI).Methods: Ninety-one patients with primary myocardial infarction were enrolled in this study. The quantitative measurement of coronary blood flow was performed using the mean CTFC method. Plasma tHcy levels were determined using enzymatic assay from venous blood samples. Multivariable linear regression models indicated were used to estimate the effect size (β) of plasma tHcy levels on mean CTFC levels.Results: Compared with patients with the mean CTFC ≤ 23.61 frames per second (FPS) group, there were increased plasma tHcy levels in patients of the second, third and highest mean CTFC quartiles (P < 0.001). Linear regression models indicated that plasma tHcy levels were positively associated with mean CTFC levels (adjusted-β per SD increase: 1.96, 95% CI 1.20 to 2.73, P < 0.001). Compared to the tHcy ≤ 12.30 μmol/L group, the third and highest tHcy-quartile groups had higher mean CTFC levels (adjusted-β: 2.52, 95% CI 0.39 to 4.65, P = 0.023; adjusted-β: 5.07, 95% CI 2.98 to 7.16, P < 0.001, respectively; P for trend < 0.001). Moreover, this positive relationship was modified by diabetes mellitus (P-value for interaction was 0.046).Conclusion: We found a positive relationship between plasma tHcy levels and mean CTFC levels in patients with AMI. Moreover, diabetes mellitus played an interactive role in this positive association between the plasma tHcy levels and mean CTFC levels.Keywords: hyperhomocysteinemia, mean corrected TIMI frame count, acute myocardial infarction, slow coronary flow, coronary microcirculation dysfunctionHu FLu FHuang XCheng XDove Medical Pressarticlehyperhomocysteinemiamean corrected timi frame countacute myocardial infarctionslow coronary flowcoronary microcirculation dysfunction.Medicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8161-8172 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyperhomocysteinemia mean corrected timi frame count acute myocardial infarction slow coronary flow coronary microcirculation dysfunction. Medicine (General) R5-920
spellingShingle	hyperhomocysteinemia mean corrected timi frame count acute myocardial infarction slow coronary flow coronary microcirculation dysfunction. Medicine (General) R5-920 Hu F Lu F Huang X Cheng X Relationship Between Plasma Total Homocysteine Levels and Mean Corrected TIMI Frame Count in Patients with Acute Myocardial Infarction
description	Feng Hu,1 Feng Lu,2 Xiao Huang,1 Xiaoshu Cheng1 1The Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 2The Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of ChinaCorrespondence: Xiao Huang; Xiaoshu ChengDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330006, Jiangxi, People’s Republic of ChinaTel +8613607089128Fax +86-791-86262262Email drxiaohuang@163.com; xiaoshumenfan126@163.comObjective: To explore the relationship between the plasma total homocysteine (tHcy) levels and slow coronary flow (SCF) measured by mean corrected TIMI frame count (CTFC) in patients with acute myocardial infarction (AMI).Methods: Ninety-one patients with primary myocardial infarction were enrolled in this study. The quantitative measurement of coronary blood flow was performed using the mean CTFC method. Plasma tHcy levels were determined using enzymatic assay from venous blood samples. Multivariable linear regression models indicated were used to estimate the effect size (β) of plasma tHcy levels on mean CTFC levels.Results: Compared with patients with the mean CTFC ≤ 23.61 frames per second (FPS) group, there were increased plasma tHcy levels in patients of the second, third and highest mean CTFC quartiles (P < 0.001). Linear regression models indicated that plasma tHcy levels were positively associated with mean CTFC levels (adjusted-β per SD increase: 1.96, 95% CI 1.20 to 2.73, P < 0.001). Compared to the tHcy ≤ 12.30 μmol/L group, the third and highest tHcy-quartile groups had higher mean CTFC levels (adjusted-β: 2.52, 95% CI 0.39 to 4.65, P = 0.023; adjusted-β: 5.07, 95% CI 2.98 to 7.16, P < 0.001, respectively; P for trend < 0.001). Moreover, this positive relationship was modified by diabetes mellitus (P-value for interaction was 0.046).Conclusion: We found a positive relationship between plasma tHcy levels and mean CTFC levels in patients with AMI. Moreover, diabetes mellitus played an interactive role in this positive association between the plasma tHcy levels and mean CTFC levels.Keywords: hyperhomocysteinemia, mean corrected TIMI frame count, acute myocardial infarction, slow coronary flow, coronary microcirculation dysfunction
format	article
author	Hu F Lu F Huang X Cheng X
author_facet	Hu F Lu F Huang X Cheng X
author_sort	Hu F
title	Relationship Between Plasma Total Homocysteine Levels and Mean Corrected TIMI Frame Count in Patients with Acute Myocardial Infarction
title_short	Relationship Between Plasma Total Homocysteine Levels and Mean Corrected TIMI Frame Count in Patients with Acute Myocardial Infarction
title_full	Relationship Between Plasma Total Homocysteine Levels and Mean Corrected TIMI Frame Count in Patients with Acute Myocardial Infarction
title_fullStr	Relationship Between Plasma Total Homocysteine Levels and Mean Corrected TIMI Frame Count in Patients with Acute Myocardial Infarction
title_full_unstemmed	Relationship Between Plasma Total Homocysteine Levels and Mean Corrected TIMI Frame Count in Patients with Acute Myocardial Infarction
title_sort	relationship between plasma total homocysteine levels and mean corrected timi frame count in patients with acute myocardial infarction
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e559cddea1b14dbfa1eefb82ccd82d3d
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Relationship Between Plasma Total Homocysteine Levels and Mean Corrected TIMI Frame Count in Patients with Acute Myocardial Infarction

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