Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis
Perivascular cells are essential to the formation and stabilization of new blood vessels during angiogenesis. Here, Hess and Kelly-Goss et al. show that the stem cell pluripotency factor Oct4 promotes perivascular cell survival and migration required for angiogenesis in contexts of tissue injury and...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2019
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| Accès en ligne: | https://doaj.org/article/e55a3bf1dfe040a6ab7dfaf6ab1c2344 |
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| Résumé: | Perivascular cells are essential to the formation and stabilization of new blood vessels during angiogenesis. Here, Hess and Kelly-Goss et al. show that the stem cell pluripotency factor Oct4 promotes perivascular cell survival and migration required for angiogenesis in contexts of tissue injury and hypoxia. |
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