Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis

Perivascular cells are essential to the formation and stabilization of new blood vessels during angiogenesis. Here, Hess and Kelly-Goss et al. show that the stem cell pluripotency factor Oct4 promotes perivascular cell survival and migration required for angiogenesis in contexts of tissue injury and...

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Main Authors:	Daniel L. Hess, Molly R. Kelly-Goss, Olga A. Cherepanova, Anh T. Nguyen, Richard A. Baylis, Svyatoslav Tkachenko, Brian H. Annex, Shayn M. Peirce, Gary K. Owens
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/e55a3bf1dfe040a6ab7dfaf6ab1c2344
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spelling	oai:doaj.org-article:e55a3bf1dfe040a6ab7dfaf6ab1c23442021-12-02T16:58:19ZPerivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis10.1038/s41467-019-08811-z2041-1723https://doaj.org/article/e55a3bf1dfe040a6ab7dfaf6ab1c23442019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08811-zhttps://doaj.org/toc/2041-1723Perivascular cells are essential to the formation and stabilization of new blood vessels during angiogenesis. Here, Hess and Kelly-Goss et al. show that the stem cell pluripotency factor Oct4 promotes perivascular cell survival and migration required for angiogenesis in contexts of tissue injury and hypoxia.Daniel L. HessMolly R. Kelly-GossOlga A. CherepanovaAnh T. NguyenRichard A. BaylisSvyatoslav TkachenkoBrian H. AnnexShayn M. PeirceGary K. OwensNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel L. Hess Molly R. Kelly-Goss Olga A. Cherepanova Anh T. Nguyen Richard A. Baylis Svyatoslav Tkachenko Brian H. Annex Shayn M. Peirce Gary K. Owens Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis
description	Perivascular cells are essential to the formation and stabilization of new blood vessels during angiogenesis. Here, Hess and Kelly-Goss et al. show that the stem cell pluripotency factor Oct4 promotes perivascular cell survival and migration required for angiogenesis in contexts of tissue injury and hypoxia.
format	article
author	Daniel L. Hess Molly R. Kelly-Goss Olga A. Cherepanova Anh T. Nguyen Richard A. Baylis Svyatoslav Tkachenko Brian H. Annex Shayn M. Peirce Gary K. Owens
author_facet	Daniel L. Hess Molly R. Kelly-Goss Olga A. Cherepanova Anh T. Nguyen Richard A. Baylis Svyatoslav Tkachenko Brian H. Annex Shayn M. Peirce Gary K. Owens
author_sort	Daniel L. Hess
title	Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis
title_short	Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis
title_full	Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis
title_fullStr	Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis
title_full_unstemmed	Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis
title_sort	perivascular cell-specific knockout of the stem cell pluripotency gene oct4 inhibits angiogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e55a3bf1dfe040a6ab7dfaf6ab1c2344
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Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis

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