Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis

Perivascular cells are essential to the formation and stabilization of new blood vessels during angiogenesis. Here, Hess and Kelly-Goss et al. show that the stem cell pluripotency factor Oct4 promotes perivascular cell survival and migration required for angiogenesis in contexts of tissue injury and...

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Autores principales: Daniel L. Hess, Molly R. Kelly-Goss, Olga A. Cherepanova, Anh T. Nguyen, Richard A. Baylis, Svyatoslav Tkachenko, Brian H. Annex, Shayn M. Peirce, Gary K. Owens
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/e55a3bf1dfe040a6ab7dfaf6ab1c2344
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